Search Results - ennio+tasciotti

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Ponatinib-Encapsulated Biomimetic Nanoparticle to Treat Osteosarcoma
This invention is a novel formulation of ponatinib which allows for targeted drug delivery to osteosarcoma tumors. This formulation utilizes a biomimetic lipid-based nanoparticle (NP) embedded with leukocyte membrane proteins (a.k.a. leukosomes). Previous iterations of leukosomes have demonstrated improved targeting of inflamed endothelium. Due to the...
Published: 7/23/2020   |   Inventor(s): Francesca Taraballi, Assaf Zinger, Ennio Tasciotti, Tomoyuki Naoi, Gherardo Baudo
Keywords(s):  
Category(s): Clinical Area > Cancer, Research Area > Cancer, Research Area > Nanomedicine, Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles, Technology Classifications > Therapeutic > Small Molecules
Neural/Glial Cell-Derived Nanoparticles to Restore Neural Function in Alzheimer’s Disease
This invention is an engineered biomimetic nanoparticle (NP) that integrates neural or glial cell membrane proteins into lipid-based nanoparticles (a.k.a. neurosomes). The integration of these neural/glial cell proteins within the NP shell enable precise targeting to treat a variety of neurological disorders resulting from trauma, neurodegeneration,...
Published: 6/1/2020   |   Inventor(s): Robert Krencik, Assaf Zinger, Ennio Tasciotti, Caroline Cvetkovic
Keywords(s):  
Category(s): Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles, Clinical Area > Neurology, Research Area > Neurology and Neurosurgery, Research Area > Nanomedicine
Biomimetic Anti-Inflammatory Membrane for Chronic Wound Healing
The invention is a collagen membrane functionalized with mannose for the treatment of chronic wounds. Due to its mannose coating, this membrane is able to induce the polarization of macrophages to an anti-inflammatory state, resulting in less overall inflammation during wound repair. Stage of Development In vitro data: Membrane synthesis and characterization...
Published: 6/1/2020   |   Inventor(s): Ennio Tasciotti, Francesca Taraballi
Keywords(s):  
Category(s): Technology Classifications > Medical Device > Implantables, Clinical Area > Metabolic Disease, Inflammation, and Immunology, Research Area > Immunobiology and Inflammation, Research Area > Regenerative Medicine
Implantable Patch for Controlled Drug Delivery
This invention is a biocompatible, biodegradable, multi-layer implantable patch for the controlled delivery of bioactive molecules. The biocompatibility of this patch facilitates the release of a precise amount of drug or other bioactive molecule to a specific region of the body over a desired period of time. The implantable patch has been utilized...
Published: 6/1/2020   |   Inventor(s): Francesca Taraballi, Ennio Tasciotti, Federico Urzi
Keywords(s):  
Category(s): Technology Classifications > Medical Device > Implantables, Technology Classifications > Therapeutic > Drug Delivery, Clinical Area > Pain, Clinical Area > Orthopedics and Sports Medicine, Research Area > Regenerative Medicine
Thermo-sensitive Hydrogel for Left Atrial Appendage Occlusion
This invention is nanostructured radiopaque, biomimetic, anti-coagulant, and thermo-sensitive hydrogel which is injected directly into the left atrial appendage (LAA) to occlude the space thereby preventing clot formation and subsequent atrial fibrillation and stroke. The thermo-sensitive properties of this hydrogel enable it to be delivered percutaneously...
Published: 5/29/2020   |   Inventor(s): Miguel Valderrabano, Ennio Tasciotti, Francesca Taraballi, Cristina Lupo
Keywords(s):  
Category(s): Technology Classifications > Medical Device > Implantables, Research Area > Heart and Vascular, Clinical Area > Cardiovascular
Apoliprotein-B Functionalized Nanoparticles for Targeted Delivery to Atherosclerotic Plaques
This invention is a proteolipid nanoparticle platform functionalized with apolipoprotein B-100 for localized delivery of therapeutic compounds to atherosclerotic plaques, termed aposomes. Apolipoprotein B-100 is a crucial functional and structural component of low density lipoproteins (LDLs) and therefore plays a critical role in cholesterol transport...
Published: 5/29/2020   |   Inventor(s): Ennio Tasciotti, Roberto Molinaro, Christian Boada Sandoval
Keywords(s):  
Category(s): Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles, Clinical Area > Cancer, Clinical Area > Metabolic Disease, Inflammation, and Immunology, Research Area > Heart and Vascular, Research Area > Nanomedicine, Clinical Area > Cardiovascular
Periosteum-Like Scaffold for Bone Regeneration
This invention is an implantable, biomimetic scaffold which mimics the native structure of the human periosteum and is independently capable of regenerating bone tissue. This periosteum-like scaffold is composed of three layers comprising 1) a non-porous compact collagen layer, or a fibroblastic zone; 2) a collagen/elastin layer, which permits vascularization...
Published: 5/28/2020   |   Inventor(s): Francesca Taraballi, Ennio Tasciotti, Silvia Minardi
Keywords(s):  
Category(s): Technology Classifications > Medical Device > Implantables, Clinical Area > Orthopedics and Sports Medicine, Research Area > Regenerative Medicine