![](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAN0AAADJCAYAAACngzeXAAAAAXNSR0IArs4c6QAAAARnQU1BAACxjwv8YQUAAAAJcEhZcwAADsMAAA7DAcdvqGQAAEgUSURBVHhe7X0HdxzHle7+gHf2nLdnz1vvPvut1pYtZ8uWbEuyZEUqS1awJSoHi1SWSEmUKIlKzDnnnHMGwQCSYCZIIgci58BMMCeQ1H313eo7U9PTM9MDYIABpy/Od2bQoaqnu766oW5V/wt54oknbSoe6TzxpI3FI50nnrSxeKTzxJM2Fo90nnjSxuKRzhNP2lg80nniSRuLRzpPPGlj8UjniSdtLB7pPPGkjcUjnSeetLF4pPPEkzYWj3SeeNLG4pHOE0/aWFqNdP/yL//ioRXgybUvHuniDJ5c+9LqpPOkeeLdv8QRj3RxIt79SxzxSBcn4t2/xJG4J92VK03UcKyakncupe3Z6+nU+UZrD9GFS+fozIWT1n9avv/+KjWePUpXr16xtgTL9+rv5LnjtCtvE63etoCqD5VR05VL1l6i85fO0unzgeVeUeWdUOXiMxbikS5xJK5Jd1URaGxyL+oyrhNN3TCQBiz5kF4ecztllu/k/Ut3TKUBy9/n40RAyhdH3UIHGmusLcGyp2QjPT/iT9R30bs0LWUQdR1/Pw1a1o2amjTx5u8cQ/0XfkhXr3zP/0MOHKujV8fcQQ2N1daW1hWPdIkjcU26pIw59MnMZ+j46cPWFqKVe2dQj5md+fvi7ZOoz5K3WLuJnFIa7Jmhv1ekcybHMVXWK4q4qQUrofJYTp5tpC/nvUIzNw/l/2dvG069574bSLqjdUzU+uOV1pbWFY90iSNxS7pLTRfps9kv0Nb8JGuLlqtXr1LloUL+vnj7ZPpm4evKVDxGpy+cYFMTpHhmGEjnrOnmbhtJY9d+Zf3nlzSl/d6e9BBduHheabrR9NXsLnTizHEu9+zFU1RSn8+kazheZZ3RuuKRLnEkbkl3+OQBen3MPVRWt9/aEizLdk5ngvWc+zx9PvcF+mLui9Rj1jP0xMBf0METtXwMNFvdsXK62HSB//9mwT9pwc6x/N2Ug8fq6blhf2RCL90zhbVlzzlWufNepO4znqa/D/ltSA3aUvFIlzgSt6RrPH2U3pn4KBVV51hb/HLZCnpA04EUVYeLqOZoKdUeLaOC2n30j6E30pFTDVRcn0ODln5EE5J707i137CW7LP4LUfS1R6tpJdG3aY+y2nR7vHUc8bLVHWoWJerSJteuo2eG/FHT9N50mKJW9JBei9+k9ZlLrD+03Lh0nnqvehNajxzhAMpfZe8bfPpGunZYX9QmrKetuSvovJDBby939J3qaAmg8sbsOx93mbK1oLV9P7kx+nKlSs0b8co6jPvPfo+IJBSTy+M/LMinefTedIyiWvSbd+fTO9MepgK67L5//MXztGYtb2UGfky/79w6wT6dtEbAdFLDAU8Nfg3ihx+M/DwiXqlEV+ig421PMzw1qT7ada24ey/QcoOFDDhVu6Zxf/P2jqUvpnzZkAgpeFIDZuyXiDFk5ZKXJMOMjN1CH088+/KPPyaBix9nz5SvlXV4WLetz5jCU1K6aM0nZ8cZy6cok+UX3fk1AH+v+ZYGfVd/jbtLtrI/0Pgt3Wb/gQNXt6Nxq75SvmBz9LUDYN85E3KnEMTk/sFaLojjQfZx4MGjYV4pEsciXvSQTCYffBYndJ0Z60t7qTqUAl9u6AL+3xOAlP1+KljMnLQruKRLnGkQ5CuqamJpm4awJki0cjg5R8p/68LLdw5lmakDqIDx0MPmLe3eKRLHOkQpLvUdImGrPyYzl48bW1xJ8fPHOYMkrpjFRyVvKg0W7yKR7rEkQ5DumGrPomadB1JPNIljnikixPxSJc44pEuTsQjXeKIR7o4EY90iSMe6eJEPNIljnikixPxSJc44pEuTsQjXeJIwpMOydJ7ijfT9E2DaerGgbQ+ayHnZ7a1eKRLHElo0mGqz5SUftRlQieavnEQLdo5jvMwe855IWC2eluIR7rEkY5BukuXaPiqHnTu0hlrS+vIzv3reemGQyfqrC2Yq3eZes5+kefftaV4pEsc6RCkQ+7lwGUfUPmhfDp4soYOnKhuEQ6e1LPKv5r3Gk3ZPIC/m7K/JpOeGfoHajxz1NoSe/FIlzjSIUi3rTCZPpz6JA1e0qPFGLT4Exq5shfPMICW21Oy2arFL0dPHaC/D/0dHTt90NoSe/FIlzgS96TbmLuMvl7wT6o+UqqcMKIrl6+0CiDvTn2YUnKX8HdTMOn16cG/pqMe6TyJgcQ16bYVJtF3C7vGLKiB5fw+nP4ENV31LzQLwTSiT2c+R5cvN1lbYi8e6RJH4pZ0W/KS6NM5nenwyQZrS+sL1lP5eNbfacCKD6jswH6eArRox0R6ZfQdlFe9ly5d1iuItYV4pEsciUvSbcldTT1mPhuz5e5MQbBk4rrevBbLmxM7Ub+l71BJfR77fAOXfxiw1kosxSNd4kjckW5z9kpe1TlWS92FkotN53lQHGN3Ijv3b+Axu6OnYu/beaRLHIkb0iEzJHnffOo191VeZzJeJCV7GX057+WYazyPdIkjcUO69emLqe+id+hEG46NuZW9JanUffpTVH5Ar6EZC/FIlzgSF6RbpwjXY0ZnOnn2uLUl/iSzfAd9OPUJKmvIt7a0rnikSxxpd9KlZC6jj6Y/3SZBk5ZKTmUafTD1Mao+XGJtaT3xSJc40q6k21SwjD6Z9SzVt3HQpCWSXbmbPp/zou8FJa0lHukSR9qNdJvylvNrrty+ZNFcxbm9ZWteUqtHWD3SJY60C+nWZMynN8bfRwOXdQvI+rh0+SINWdU9IOt/b3EqfbfoTfp2wRv8mqv1mYsDwvoi1YdLeen1y1f85V25eplmbRlGWeW7rC2Bkl+9j9/kevzMEWuLXpZ9asoAqjscvjOAj/fxzH9QSX2utaVl4pEucaTNSbchZykNXN6NNuetoPcn/43OnvfPkTt/6Rw9OeRXVHFIv5Nux/511EWRc8We6ZRbnUabcpfRO5MeovnbxvB+U3Kr9tCrY+6ki0YWCd4jDmKszVhobQkUZL3c8vn/ojHJvawtGCw/Qu9OfpQKKyOTKb96L3047QkqbgXieaRLHGlT0qXkLqLP5jzPL8zPrNxOH055is5d8M+Rw+B05+E3UfWREl5C/d0pj9Ku/SnWXi11Ryt5doB9LA9a682JD/B8OJHLStN9Me8l2pAZnNQM2Zq/hp4bcRO9NuavtKtoA29rVNfWbdpTVFTlLkqZW5VG3dXx5Q2hX17pRjzSJY60GenW5cynT2cjtUsHINIrttIb4+6l7QXrKL1su8I22lm4gZ4e8lvOgSyqzaXnhv+Rzl4InC0O3+7jqZ35jT2m4N1zr4y+XZEnhV/giPLSijcprfUIbcxeZh0VKJtzV9Fnc5+lDVmLFdGeJLxyGa/aioZ0kOzKXfwW2Jb4eB7pEkfahHTJ+xZQD9W4zfeAQ9M9OehX1FWZj28pDQV0ndCJHul/PTde+Exdxz5AFxUR7DJs6Wf8QhBTCmuz6ImBqjxVhpT3pvr+1KBfU2ruaj4mpyKNVu6YQ4catc8I0n0060n+/t2iN2jWjpGK5KeiJh1kd/FG+mz2c1R/rHnvr/NIlzgSc9IhefjZITdRxcFA82tfeaoyL590NC9hOpbW59OLI24J2A9BELPHzM60KWe5tUULm5cT7qemy/5pOgiqfK400OaclZS0dw6NT/mWNiqfEuuinL94ln267rOe4GNrjpTRG+PvVb7mci4/WtJBZm8Zroj3vGNHEUk80iWOxJx0WZU76Pnhf6Lei7vye8RFQLoPpjyhNIuzT3dJkafb9Kd48NyU0iN59Oq4vwYNpoN0XRXpEAEVQSCl59wXKCVrKZuAMil1RupgOnyigX06IR1kdfosembYjUr7dqKSmuh8tPTSLfT6uLvpvcmP04kz0WfWeKRLHIk56faVbaGlaZOp/7J36Z0pD3NoH7K3bDO9M/GRAJ8NpHt6yG980cvsip302ui7aM6WkbSjcC2t2DudXht3Jy1Lm8r7Tcmt2kuvj70rYA4cSIfxtHUZi6wteKXyWhq8sjt/35Szgt6f/gh/h8Bf/G5RF3qw9/9QaU2htTWy7C7bSC+NvJWSM+ZS30XvBnQubsUjXeJIzEm3t3Qzrcmcqwh1ngnw/LA/scmJQfElu6Zw8EIEJJm+eRAdO33I2qI0W0MujUz6jL5e+DoNXP4B7VPlOQ2UNxyvofnbxwVEL69cvUKr9s6kolr9zvKNOctowNJ3fTPRcR3L9kzm7yJ4p/iUlAF0uNF/DeEkJXsJPTzgJzRv2xhl2l6k7xa+6ZHOk7DSJqSD2QbBIPTbkx+izsNupsKaLN7mVuoP17QoKwVrrXwy41kqqy+goycP0eXLfnJCMEO98qDWwm7kypUrtGjnBLr72/+g4as+pauK4BeaztN3CwLNaLfikS5xpE1JBzl4oo5eH3MXPTno17Q5d4W1NbxgsdmhK1u22OyKPTN4Qdl5qWNp/pbxdPLMCWuPlk05K2nqmqHWf+HlzIWTNHRFD7rn6/+kQcpUPd+kX8t8oemcRzpPIkqbkw5SXJdL/xjyO7q/949o7rbRbAaGk7Z4lwEinNOSh1n/hRb4oF/MfZlu7/W/6cs5r9L5i/4l2D3SeeJG2oV0EAxeY5zu3m//i8au/YJTwEJJvJAOKWKfznmO7uj1b/TB1Mfp5Nlj1h4tHuk8cSPtRjrI5tyV9Ei/n9Ld3/wHzzg4F4JU8UC6miPlPOB+x1f/Ru9MftBx3RSPdJ64kXYlHQRrTz7Y97/pnm//k75a8BqnYdmlvUlXUJNOL4++je76+v/QM0N/T+UHnMfwPNJ54kbanXSQuVtH0gN9/h8TDwPitUcrrD1a2pN0qbmreMAe1/bUkN/SjqK11p5g8UjniRuJC9JBZqYOpXu/+y/Gy6P/QlnlO6097Ue6FWnT6ZG+P6H7vvu/9LeBv6Dt+5OtPc7ikc4TNxI3pEP6Vu/Fb3ED79T7hzzbIDVvFe9ramPSXb36Pc3eMoIe6nMdR1gf7vdjWpsxn/eFE490nriRmJNud0kKrdg7zfovvCBnsceM56iTIt4DfX5Ej/f/GWeRXL58hQegY026GWtH8GzzkWt6Mvkf6PPfbPYu2TXROiq8YA4ghhGOn/LPRHcrHukSR2JOOkzTqTjkPo8RichdJ9zH2u7BvtfRY/1/yu8XAOlCRTdbQzDjYNjiLzhH9L5v/0tpt/9h4k3d2N86IrJgVsPOwvV08dJ5a4t78UiXOBJT0iHHMSV7Ma3NmkeFNTr/UaTsYD6V2RZvPXH6OBXUplNRXRY9N/wmJt5DinjQOO9PfSxg/ZPWFiwN8cSAX9H9SsPCnLz32/+kT2d15pxRN4Ic0m0Fa2hd1gL+vHDRf96p842UWb5dkTFwyk9BzT7O9YR4pEsciRnplu6cQu9PeZwGLP+AzbWPpz9DA5d9SOfO65Sp4Uk9aMTqnvxdJGP/bnpj7L108twxKj+4n14Y+Wf2qUCEV8b8hfaUbqTMym2UUbG1VZFTvYsDOQ/3u16RXGu47jOepCMu3xhUebCI59F9Oe8VGrfua/pq/ms8ETa/Kp3359fupVdH/5WOHDde+fU98TmLd0/gfz3SJY7EhHRZVbt4qkthbSb/Dzl7/gyvFzk6SS8CNGLNpzRy9ef8XSSzcA91GXef7w2oeF3VU4N/zaR7VJmZd3/zAx5IjwXgRz7S7ydsWr496UE6dKKeryGSNCnti8WPMIHVlDXpc9VvuZcToffXpfMUpaPHA309vNt8cZr2Fz3SJY7EhHT9l7xHY9d+xd9NwXJ6aHynzp2gMeu+pGErP+HJqniB/6UrF2l3Xip1Gd8pYGrPmvR59I8hN9LTg3+j8NuY4qlBv6E3J94f1Von+0q38Pvsjp8OJBRmpn8yozO/v7y4IZt/d+2hKrpw+RwnSCNn89NZz9GStEl8vEe6xJHWJ50ym+ALOUUsMUn19XF3cWBlyqZ+9LdBv6CuEztRl4n3UddJnejFUbeq/XfS8TN+MwzTeQ4db6CGI9UKNTFF/eFqOnmm0arZnazLWkjvTnnY+i9Qxq7rRbO3DqPKw0X05OBf8QRc/FbBowN+Siv3zeBjPdIljrQ+6ZT0UKRblhY4ORSCIYHXxtxJVYdLaNz6r6nf4nfoYGMtr/518EQNrd+7zDIv3U0gjQcB6d6e9JD1X6CMXvMFDzcgaPTKqDsot2IfNTRWcfCk/lgV+31LPU2XcBIT0s3cPJzXm7RP2cEyC+9NfpS/j0ruqfy7L/m7SFbhXuo6/v4ORTosaIQgCaYrmXLoRK0yle/lIZCi+kz655h76Fhj4KD553NeUual59MlmsSEdCeVRgO54NchG//0+ROUmr+CnhvxR16jBOIcvUyjN8Z2LE0Hmb1lGHWf9jSv/4KE7ZqjZdRj9jPq933G+wtq9yli3ukQvXzBi14moMSEdBC81Wb4qh70wog/K7LdTN2mPuVbRRkyMeU7mrS+j/WfltySDG68pk/XEQQRyqW7p9CryoTEb0VgZcamoezDQorqs+iDKX8L1HSKdH0WvUWr0mfyvx7pEkdiRjoIFgkCgY6cPkDnjcFiyLmLZxT0mJ0IXiYCrXj1++AXhMS7IOADLXfk1AH+NNdzuXy1iU7hd9lefIKXleBd5xCPdIkjMSWdJ+7Fu3+JIx7p4kS8+5c44pEuTsS7f4kjrU46Dy2DJ9e+eKSLM3hy7Yv3lONIZsyYQUOGDLH+8+RaFY90cSJvvfUW3XjjjZSdHTjv0JNrT2JCugkTJtCAAQPowgX/G3Q8CS9lZWVB71e4FgTjlfhdaAvnz5+nS5cu0cWLFxmnTp2iw4cP0/Hjx+n06dNB45jXqsSEdAcPHqRXX32VrrvuOpozZ4611RNTTpw4QT179rymOia8VOXcuXNMoEOHDlFdXR0dOHCAKioqqLCwkPLy8vhz//79VFxczMD3oqIi/iwvL78mOx67xNS8TEtLowcffJAbmCd+2bJlC/3whz+k9957j86cCXzTbDwLSAWAGCdPnmSAVCUlJaypq6qqAkgFMuH/Iotg+D8ccGxpaWmHuifNkTb16fBQcHMTWaD5YQGAePEuTU1NdPbsWTp65IgyAw8xcQoKCvgTBCkEuYQw6jv28Xbep8hmfedjCi0CWsc7Qh2zv2A/n3v0aPTLGHYUaVPSrVixgv793/+de/hE1X7oxeOxJ7908RKdPXeGDhyqp8rKSqqvqaWSomIqLSymEkWC4oJCKlGkAIrV//LdRLHDtuaAy1ckrK2uocuK+NeatCnpIOjBEKkD+dC7XesCnw2+G7R8XMj3pBryZdXpNdLBIw1UWJlH+dXplFm1jdIq11NG+VbWNCBakdI6xQpMuhBEixVA8qL8/VSh/LxrLSDX5qQTSQTCwaf9+c9/zkGl9tDsiBzCRERgo66hhuqPVlNhbTbl1uymtIoNtLtqLe2sTqIdVavVJ5BEe6tSlA8GbaM1jsCJGLGE1AntiQALIp3XirQb6UxZt24d3X777ZSerpesuxYEhPvBD35AS5YssbbEXqARYLo2NDSwZq2treXARElxKWWU7KAdlasscq2mXYpgGmsCkFa1jvYX56sGr8xKgwRtA8ucNeoWnxHA8II5ZaqjSlyQDtGwKVOmcETvjTfeuGac6FhpNxn7QvmNxxvpmLpf8MPKy8o5klisfDFEEDlwASitlVO6L4hgoZBfkhPQ8GMDTTBNMpBrPxUU51Cuus7csj1qm1/TIcAiwRh0KB19PC8uSCeCRgT/B+HnjiYgAVK4WntcEiF6DCifOHGSDjQcpIMHD7GfUwGCqUZYmF/Afld4E7BYNehsR4IFI4nyStJ9ZIgFQLDC4lyuB29nSq/YrDTselV3Mpu40LY4Jug8mLrK12uor+f70lElrkhnF2g85CPGu8CUg3l81113tShgAv8L5uG5c+fpRONJqq+rp/r6OiopL6S80kxKL97OC/IW5u+nIiZboS+6aG+ggSimwqJ8bszORDORRNllu2JAOqV9lSZLr0ilPVUbVD2aYALT1N1dvVaRMo/PMcsoVRocwR0EejA+iM6oI0pckw52/C233EI333wz7dixw9oaXwI/6vrrr6cxY8ZYW0ILzEKYRlpznaBjx47xJzJ4KiurqLKqkgoK8yinKIOyStMovXwr7alMod2KLLpxrqaMim26MSqT0WyQkVBcVEh7KzcGNG4noB4sNR9MumB/Kxrg3PySDItgznWbyC/JDLqGUusTpibMZ/irHZF4cU06EZhs8PfaMigRjZghbZiZyCtEY4DWArFAKqRFQQvCdEY0Do0GwIAyPjNLdtOeihRKq9bayEkD4Pu+ys3c6MzG6A7FrGUiN/okRc5NfA4aPVCs/KvCojxlDmbwZ3DZ7gCTEhFT53r9wDXmKL/OTjpfOZa/CiDFrKMNKXQI0kFwY82b2543GibvRx99xKQ6e+YsnTt7lkl1SJGrqlJpKxAJ41sc1LAaCUjGppFuMByRsxpQsWpcGeXbVWNDVNG5IQrg+xQ5+DuRgAacVbbTBel0BDNf+Vs5ZWms9fZC2yqTD9eHbaHIEAnw07TvFv4acI2Z5TtC1lNqZcRIalm56sgunI/+9WTtJR2GdKZAY2BwPdYzGWAKCpAOBYJ06tSJfvnLX1Lqxk3s2Bfk5rFvxQ0CJl8BGniJ+t99w0Tjyi3d64oQu5UvpLVNdA0/mjo0cFygttVk2N5s0gH7lBaNdA3Yv69is+P5oQALAs+oI0iHJB0EN/mJJ57gPMakpCRra/QCPwumoJiEjY2NPB4EkxA+A0w/aCz0qLfdeiu9+/bbTDQ0vPKiUiorUtpMEQ0OftH+fI4SonE7BQJCAWXBh4mkAQRO/k4k4PiCkiyrDDOAoQMXILNZhxM0GVIdy3eHYiZtJNLh+vZUbmCzFufh2gV6KMEfOIKfx1FNmNzqeSEJO96lw5JOBInD0QyqI0KIeV2Yw4UxHwwgw0zJzc1lgoFc8ilmIH8q7M/LZ23GD1qZSojG5ZXso8yy7VbYW/wxZYaVhvZJgoHIXhT+TlRl+4GOAOZdWtUG9u8QpYQZie2uyaDOLy6M3rwFcM0wTyPXozoCdS8RcdX3OZfySvcp83gH+5sow96hcXJ1kTY50XHGs3R40pmCIMZnn31GNYpITeo7ej1EByUzA2apzO2C9gK58L2QH5qCIpgJTMa96aab2EfD/+hh8cBBMIS9tXYIDnjg/2jNMDRkt/5Ols/fMTUA4NcAzlC/VTXg4qIC63//+e7JIOF8e9mRgXoQjHEq1wnwJWV4Qe4zOrT0ii2qvMB7y4PoxrM7dTp+08Y6NOkkMwMBjSOHj1BVRSW9o8y/f/3Xf6V3332XMjMy2OzgB6JMEADffVBaC9ka/F31kugtcXxWZia98MILnMY1e9YsXYYCHi7C7jrgEa6BNs8Mc+vvQEvpiGI+m5ogDBKV0Uhh3tobZCCc9ulwvlN9TihQdYavIxSKmfSaRGaZwR2XbHfahmcgpqcPRcX8jOB3F8ElUN/R4cajdBjSIZiBWcnQXpiRXFNVzVM/ykpKqbxY+Vz52uSBfb81dQs9/thj1LVLF99DcVp5ywloGO+89TY98vDDlL53n+98Dfgk2yISA2CfJKooo1t/R/tgaHhijuIcjdVshmnN51RHaLB569Kvg8/qr8OubYPLNlGktKyMO4JAMMnxW/Db0Zk41WmHjuCGyQ9VbQCf6EzjMVE6LkkHgsHvQnZ8dXU1j2vBNJQwMXoxpD+ZROMbbflbAQ9AAQ/IiWBOQONB2fYyAOxzbYYhqyJcw7BBl72bieMvR8jkVF/wNhwHP81tnSZ0OB8+afjfhjqQuqVJpp5DUR5r22x17RmqQ9JkcK4DgIbKVufj+PySLOse4feXqA4j3bFOJ8CfDvU7kbnCU4NUXQi4oS3Fk7Q76WAiIrghmRkA/C74YLDNzWCGzFhGD+ZujhfSn/LY+RdShWrEJumcy9LEiCarAtHCcOWZwHHIRZTrg9ZBjw7/Jbt8l+XbRCaE9nec64gEN+YtrmFPVQoTTMbvsF1fN8gQybzVv1VgbnOfH7qGCWqe7wROlFZtBm0pnoYT2px00GIYW8NgMgIe0GQ8iKxuTsB0fwumcyxg0rkEzBk0WCGV0wME3JAOjQk9bMvNMHu5ej86CAxgI9Me5p5ECaEFMEjthhAgQpC/4woYoA9lOtu3SccVuB3bmp8sjYHu1sgP9W/jiCag2gyIh2GheJA2IR2CHbCtkcBcU6P8MKXyS6C1lKZixxc3BpoLpOLvehsgQQyGuqGAvrE6PYkbpy8a5wz04G5J53S+CZDYdZSRG4bqUBR5QFaQEJkW0EYox6l8/C7dmPyNB/9nu84mEX/HXm544Dph8sG89RMqmTssDFSLRgsHnNeSZGk8z+jyQ0u4LqkP7QCa1udLW+0JbQeBFp6Ffr79U8bahHRr167lvEloNNFebrSV/4Za+X/F8B8yuHGg4Uo4OVzwANsR/HBLOjfBDzcNA8D1ITigSerPqse+yFFGP/Ab8Bvd1Ak4+zv6PgZu8wN1wDcDweCzwXzj4QXWti1NlnaLaPJDN/LvxHXCOkBOqtaSydxGgq5B+fuFeQVUoywruDPtKTEnHeY9de/enf7xj3/Qzp3KAbd8Ne59zJvigILiLA4upPvy/7RZ52+8+FzNNz3Ug8Z2lOGWdKGjYrJNmWEVTmaYn1DB2wK3Y1s0ZhiOi34+nNYC+rp1h6XJ6FyHCZznPxfbQIYtDr/PDp0s3TzzVtcLwkeuR2CO3+n7jE8Eu/T163J9vj+Ip6yoAwcPspvTXhJz0iHE/+KLL9K9995LvXr1YsKxtosYBFG9q3LYA82d4BuPfehdncuQHjzDNekKSrLVObYGW5SrGmyurzyYUDuqsfSBvqa0KoTwN/FYmVt/D9ra36gjQfs7bjJWcJ/QcPE7kKmPDgJaAedq0zO8Ke4EJkPU5q3b3+YH6oE/66/HJFRwXU7AseESE9hNUa4Nhp0QxGsPiTnp6uvr6bHHHqMHHniAF55dsGABDwFENi+hUdwFDzDnDOQIVQ56eLeky1a9pG6wesAZkToQSQIUeJgYHMa14RhEKHUj0/XjWkJ1EAL8Jt1RuG+YMHvdlK0RbBHI9uYnS7s1b5OtDsrvb3HanDJTIxFe31udH4pOAp1Fpuo0ckr1M4Fv7ubewtR0Kp+hCCfZSMixbQ+JOem2b9/Omfn3338/fz777LOUkpJCZcrMdLwpFvAAoFEik05PRQn3QLFPSBUJzg1WD+IG1iENCg3Y34jdm2Ebfee4Q6C/I9cXua5ANDtZOqpw/j6+V77xO9XBIFlAZ+mEt3AQDJGOTJupcp9LOAjl5t5C20rkN6h8fGIcT33C2jrRDnmaMSfdzJkz6c4772TSCTAXDT+4rBgZ+s4PATcaD89No4Imcg4e+OFEMCc4lQ+4qQPX7M4n0Q0jdEcRXIcuWzc6nAsCoi6YzshndBtdtPs77qCHM9yZt9rE9If+/Z0XAkvusnScfz80nqv2oK5Ta/TAMoKg2mB5SWmbD57HnHR9+vShu+++20c4mJnA7JmzqLKsnLMHnG4IbrLuXSP7SHigwRGrQE2E3hbHSoOFFkVj1VkQ7vywSMEP7HM7Z02TOFedExj2BhFDNRgEQ3BPZIhEzmPTkyO54evFdUWbiC2A5gg0b01NG/n3AvjNOlk6+vpxDjSnU7lOwLGB9ZjtQf2/v4jKrLZXWVHBCfJtJTElHUKzSDw2SSd4+smnKHl1ElWonsZ/Y0xYwQPXPfhuKrMaMBohHi5IAvNG/49gSI7P7JAHgEbupgeXOnwPzQHY55+zFgmKxEqT4zrhL8F04vEwdS2hfRKj0diAczUBnOrSwP59lc2dD1fMdeyoXs3kkeEQ3F90YE71OaE55q2Al3tw2R7Q+en2oDsyPHtswzO0m7jIXMEShm0VWIkp6ZD9j2x9k3Q+/+6++6jbe+9TblZ2SG0Hmx6BjMg9qZ5pjCAI+w+qQfgfTnizkOtwG/woDx0l1bDMMBeaE0DUU47VhNFwb4YJ3E8OxVy6QH/HpgHCAJ2YzpZRnZd1fdDU6Dhcd47NnAsI4LphqUR6Vtgv1gzahbYCcJ+TuFPTgS9/uRhAb8vASkxJh1Svp59+mocL7KQT4o0aOYrXuODMAeNGCEIHJuzbnM0d/B+pdzUDFKHhFPwIbrBs6lXiIetzAq/LXqYz2AyLIsqI+tGY3dQBcqDRgSw8HFKspwdBY0Hzhq9TfmvgMfybXZAB1xdu7RM3CJ0fat8W6r4ns4ke8BuKNPHQAZ9ojP10oJiSDilfWFIBpBNfziQf8NRTT9GqVas4NYwX8zFuMB6ODh7osToBeit/72Xe0GDg+HC9q67DffADDQznYP4diKEbLGZg+32Ivco8xDUjmMBhb6WFxLRxLjsY0SZLw6eN1Og1kvl6AB6/szTUzupV3ME5le8G0cwFDD7fnabFcToxwd8eUC7us7ZWnOs1gXNCJUtjEB3BvVgvehVT0mEg/JFHHqH7lEazkw7A/9j32muv0b59qpfFGAomlVoD57gx6H3Ri6JBSONGY4ed7tcooYGbHC54gO25rrVEMg8SI62MG6zlC6IRmHXgGgFz/A6aBYETd6anPVk6EqzlHhzLxu+y/zZpsOb2SOOd4RDd2ic4R2ta/D7pvDLYZwsu2w/cD0QweZYDxkl5/E4PL7D/bz2PcMA1oh2Fbg9FVF1ZFVP/Lqakw+tuH3744QCT0gn33HMPDR4yhEpL8CDUDzd8PGgU7T+Yppzej4BDcIMKBG5yuMFSlBc6+BFcNsqzN1iuQ/kOZplOD5U7CtbQka/ZvyRDYBmhgHuEHt+vBXQngfrcdE6AHosM9HfcANep5xlGXkIQxEBHKtkynHygtuFcdGjybEMBvxO+ndxjfY90bi46Qjf3FoR1vLeqs0eHj/YXy/dpxJR0mZmZrM0ikQ77H330UR5GqCgpczFPTj9od7O4de+qietUlkRJA5f55garen7tuDuVa0JridB1+BFLMwzWAMqHuYyGrTNDsCR7NNkk7hOxBbimaNY+AeQ+y3Xp39x88xbXHNr/N6HzQx01ujUJGgSGlRarWecxJd3evXt9hBPz0oRJPJiZzzzzDO3auYvKShXxkCOnEHRjLOBBo3d105hAIH9gwuwhdVkgC7QhtBV6W0Tp9PCCXojIVR2qt44c/Ag3Z80EIpgw9fTvxCcWmJWwd6hoLK5Xfzd/H0xPd+OduC43k0ODYc4z9Hdc+I5tbsw+HItUu+aZt/o+ufPN9Vit1uj4nX5tqcvS9SM/GJOpY5EYHVPS7d69m4MoIF4k0gE49pNPPtGrbxWjoaEhBd9gADfKffBABybYfyj2Tw8CyeCLoDzRUihXHkJz6tDnhr5mDGu4aRgIcOCVUVnlu7hD0Bo3mROtw/kkwbDGIl2G9KMr2w90CvC9YaKmV6b6Oi807uiydKI3bwFcc3T5obpTxScsAVwjWwmWiYukaAwjIALf2hJz0kGDgVBuSCdacfjw4fyjw5EON8Z9YGIN2/swAf3ROt0bh59pHV0dkYIf2BcNieUadYPV5+A7fBKn8kMBv0/7O871CPxl+zsdAfyo0PdJAx2avfNCwMQ9Gdwt9+AE1BVNfii3B+XvBmrn1Uw8DCGUFPvnfra2mRlT0uFtpCCSkMkNcCyCL4sXL2bihSadDkxoDWB/oP5GGn6b1ih+U8O5DtfBjzIz+KEbLr6bZp9phpnXBA0RnRkWeJ3hAX8HaXDhf4MuWy9vh3uCCCzMa55tofxi/O//fU4I3hcNGXAPm2feAjoxAfcxuOzg34267NsAaGtobVkHFVYXzMzWfB9eXJFOjkU0E5kse/bu4SX2nG+yBhoJUpNww9CYoc3QSNw1MkAPloZ70HC83TRYCQQErEeprgPXBLKhDiExiAP/Dsdgsi7yKWHahGoMfkRKlg4G6nVXtu6EcG1YJg//4xyN5r48xApUuehQUE9zzVsAWhadg0RRUSfaB1wIPBs37QFtCBq7qEhbWmxtqc6/NVeNjjnp3JiXQjYAxwPw7957/z3KysjkdS1DRTTREOD36HEeZd6oXlqPieWom+jGLNQ5kKEftNvgBx6yHgyXBmY2WLMOEEZrP22C6U+YYdEkS4ef8WACdWgTzyxHrs2pvuBtOA73oTmEgGkKIkdq9FyH6qSaU4cA7QH+um+ctEi3Bz0sFPneAjgX9xZWlrS78tLWW8ovpqTDOwYwcdWJcICQTohmAqTDm0379O7NL+mw31wTeEjSeGWbNj3RW0d+0OEHS0MFP6JpsKsj9uDYh4ma9nOdgHrRyYQrz4S/bLk2M2F5lytCYH+48c7wiG7tk+ZGMDXElzTbgzI9W5Afyi+HUcCE7NaQmJIuPz+fZ41H0nShSAc8/OBDNGfmLE7P8d9Yd4imdzUJ64d+eIjCaRPWth6larDap3QuW8B1KC3hXIfAMsPcNgyfqafhb2hOZaMTQhRxB2tcaEkJeCAT393kUL3QUjRmrQDXJXMBA8s0ta2+tyC2XFtrgk1PR/8/ELgWXKtkRoFsPGCuysDE69ZYPzOmpMOalp07d6aHHnrIp/GEaCacSOfDPffSE48+RssWLaZKjN8V6KwBpxtrh/vBUp3I7G+4yrRQDwmRSzQy9JLmgDPMJX081qOMpo7w141y3WSPoD4x9fR16rA3fBfMzg41Xmj+PnOb+2Tp5s2HQx3adPbnTKJz0W8P0p2XvOU1FoQTuE1MwD1EG0NHX1VeQbVYwl8Bvt2RI0es1t18iSnp8O6Bjz/+mPMvARAvatIpbdfp7nvppedfoJ1bt/PEQzekw4PGw4zcmBCYWKcabjabbDgHDUEav2gUgb3Buh+DCr+khABmWKTeGEB5ONavaf1aI3KU0Q8chzVf3NQJRFO2Hzpqy8kH6n7h9Vz+zsv53rY+osgPrd5AFWWlPKsc52L62Z5du2nrlq0czWypxJR0kD179nCmCdK8hHTRmJf4jilAdyv/rnu3bvxGHV7jwjYjwQ48RLeBCQDBD2m0+hz9qQfPnRuDrqOlS0pIg9PlOZt6ck3mNt0r27fh2HDv6w4G/B33k0ObF8H0A+fq85tfhltguk6hIrZ+k08RZZVhMd0Qz6rGQi2e1Vras3cnbVckwxt3N21IoQ3J6yg5OTmqdyGGkpiTDmk048aNo8cff5zH34RwbkmH4QMB1lr5+ptvaD9e8KFuotONFuDBBiYym4SSbeGBY3mw1KF8ILiOcJDgh395BkQwYa7p+V26PG3qybKDWqPpsPc2/h5cbiBwHjoKlGW/3lCABnY9Fqk6hWjKbg/AEgJ4BXF1jxH2Ly8rp8IqvKbL+j1CMkFlMu0oSqZtOcmUmraWNqxbS+uSkmlt0hpKXpVEa1auplUrV/FCWy2dgRBz0kHw1lMsRgRtB/9OyAaYwwQmhGiYdS4A6fA5ZPDgiKRDTyqBCWgZ5DJq/2E3j4sheBKZgMiBRPAglFaNbgwKphUIhikpqF8HenQkEb4MGjPMXIwzQqPgOjnsbdWFIIMbYpgzHtwisr+DDgsvZGzucg9RwuH5Bq0wYJFLgP0Vyu+vqayi+ppaqqut5Tmd/DJQ5ZvlFWXTrqpk2lWxhnYUK4LlraXUPWtp01ZFspS1PoIlrwTJVlHSipW0avkKxmqFZcuW0aZNm/g1AS2RNiEdJCsrixedhW8XScsBJtkEGEIAHuh0P00cO55vcMBDsAGaBD4ILw9uNWqNEvfBA0UoPc/LuXdHuW60BADy4xP16rr1OegYzDrkOs068b+7jkJHGaMNSPjHIk2LwJptocqTgId+IaRzGa0JjhoyFKHw2isrigiiYV2dakWimopKJlhdVQ0dqKung/X1dKC2Xv1fzWO7OdnZtDstjbZu3cpkSdm4gTZtA8HW0Lo1a2jtqjW0ZsVq1mJJimRCMGDl0uWMFUuX0fIlSxmLFi3icvBu+pZIm5EOgoVm//a3vwUEVZwIBziRDprur3/9K91951300P0P0PQpU3nQ0umhCeyNV7aBjE4NNhjRLfcgDVb/72ZwHkjixhyuDuxznSytOoqiiDMe/EDZ0Kw4F4EZaFROWFb+KndYvmitdAbO5dghJJHwO38391mfAv2mXLVdaSwEMaoVqeqqa1hraVI1+FBfXcuRRZAxJzOL9u5Oox1bt7EPtnH9elqfvJaSFbHWKCQlJfHqBDAPVy1fqbSWBkgFMq1UxFoBYi3W5AIQLQeWKixZuIiB9rshZUOL3/7TpqTDGMenn37KY3diZoYzL0WzASCbiTvuuIPJO3v2bH4/QrgczWAgT8/pNbxOcA5M6P91I5Tgh9YIWCBJz3CHDyfaLRxwbrglJQDsQ3m4Hqcy7Ig048EOmLEwfUVD4lx9vvsyBDhPSIXxLUCTz08wEJFD8mXQWEpbKXI1gFgHDnJYHkCGP5Y/x4rM2UprYaoYfKrNmzfThg0bOLABQq1erfwtkEph5cqVtGLFClq+XBFKQb4vXbo0EEuW0JLFiznHF8QSgi1dqLF4wUKN+Qtp0bwFjAXz53O9HYp0EEyXeOONN3zariWkwycIPG/ePKrA67esh+4GOmPF3ZgYSFVWiPCxBD9ylRbQy/vJOF5BcY76jgarGys3PPW/28HzyMEPM1nauRw/ol3uQRA9wUz40qYsYoFs7GMpUtVaflZDbR0dqj9ARw4cokMNB3j8C8fAhMzNzuFo97Zt2wKIJaQCoUwiwccC8EYoAAQKBZiGJhYuXMiaC1g0XwMkW2JBti2aN58Wzp3HmKM6+HXr1nUcn84U3DSJZopvZyefBFGEdDAtAZBNANJhH4i3QBEv2qwVBA8iaw6d1Q/TTo/fIRkYDV+bkP5kaecG25rBD91RhM+qQFmYc9fSVbdwrv18k1AC/I8ABnyoytJyXxADhDp2+AgdPXSYzUGYinhVVXZ6JpuCCMdzKH7tOo4Swq9avUJrKRAJ2kiIZBLFJIv9f2C+0kZOcNqPzhpYYJFqIQhmYcEctd3C/DlzGbNmzWLN2tKJre1COiSOfv311wG+XSTSCfHspGOt99c76FFF4LkzZ3OeJpszEYAG5TaRGcBx+ljz+PAaxX0deqa4m+AHhg/85QVek/hj0Jp4n7fT+W5hkoq3KXMQ91WTq4xJBL+KfS2Fhpo6v4+VkUUZe/bSru07aMumzZSybj2Pc61LWsPE4kDFMn+QYtniJdqkU36TkMiJHOEwd+7csJCyHPcpQi2wYd7sOUGYMWMGa9+WSruQDoI5Sl27dvWN3TWHdMDtt9+uCXi7It6DD9G0yVM4uBIUXrYBhIB5aKYmoeHywGilTG60kyMQOAcBB0RDw9cRiXRWBJOHB8Jfd3q5jmDieBAQwwtYzcw+vBCqI3CCqblgIsq9g9lXW1mtSNVAxw4dYc0FkjG58gsoKz2DtRYyhbYqcm1ct0FrrVWrdbhdEWslghQSAVysfCnlN/n8JZhxSqvAX1o4V5FCNfY5c+awn24CGgawb7cD54aCEMxpnxPB5s6cFYQZ06dzJLSl0m6kg8A+fvLJJzmoIqTDgLhEK03SiVZjzWaQ7i9/+QsD5ANA4LFjx/JyfqWYBCuhZqORAWiUCExAO8j4Hf5Hw4fGQYMO1GrBQOPXydKBZQukjkjlCNwEP3S6mp62Av8SxwvCEhaEUvcCmqgwX30iwUBt50BHaSkvK45xLWTSAxjfQseIweWcnBwOYpiaC9FBaC4sjS8kw1gWSCbRv6WI+i1QpqEi10KYd9BayoyzE4BJM8tPLgBaxY7pqtEDTvvwohrzfMBOymgwC+XZMG3aNEpNTbVab/OlXUmH2bhYmkHG7kC8lpIO31EGXlyyPz8/7LQgNNrgcLiG28FzkJPD3LayNXTwI3SUNFDDYjaDvgansgQuCGZANBgPNisgFI/ghYTeEdjA4DGyNnJzc5lcO3bs4MaFV5qhY0xao8zC1XosC6F2n3m4RIfa2TxUJENYnbXXfK252B+arQimGjHIZScFiAKANEIoARq4HVOnTmU47XMio5TfHNjLAqZMmcL3p6XSrqSDYCYCXjIipINZKTBJJ2N0IJoQDLjtttsYJvEAHP91r68oPztX+SGljtouNDDT2t278TBxNVwisw5++NejBNHsA86sYYuRYe/uGsVn9f0m9QkN5htAxjHwvcrKeeCYszPUfUaQo0ptw/687Bzal7aHdm7bTps3bWJfBe+GlzA8ooW+KKEVKRQNxuNWSoOxiWhF+TgAobSYGXiASTZnutISqsE6NWSTYEKocECjB5z2ASYBnUgYDaQMuT5g4sSJHH1vqbQ76SBYHxPvJIeZaeZcmqQTbQdCiXYDhHR23HrrrXTHX26n9956m7albtHTglwSD5oEQwKuSKcI5JzI7Ed6RWrwgHMLxsPwO8wpTjgfWRrI0EBAA2Ne8jak/Jxcyty7j3Yr03Db5i20eUMKpaxV5uEaK+1JmYdCMDNyCEjkkIMbyjRcrHwvJllAlE8HHuaLP6TMxLkztA80a7oi27TpDHsDNgHCCKEEkyZP9mGyDeY++3km+Zww1QK+m8Ryc20TJkzgtwi3VOKCdBDcTORmiokZLelAsltuuSUAt91yK93251volRdfog2qocG04rEkq+GaDTkQxTwU4HbwHETSxHEqC/WFIZgvW8M83ro23h54nb78Qh77UtpLEQ2BDZAMPhuyMzANBR2NEGwdCLZ6jRHgWMEQE3Gp0mA8UIzQPMLwVng9IEKofDDRYBxoEFhBhjkzZtJsxgxFtumMmarRzpiqGreCNOIAgliYAvIoTJ7kxySlVdzAdw7Ot2DWYYfUOXWKIieuy7g2J/IDUu41R7oTJ05Q7969A3w7k3imaWmSDrAT7s9//rMP2AdgLA/mgSw0I9nngNmoBQhUuMvqj3YdSj+EbPhk8zC/gDWYJlsRa2eYhA21tRyWh5kIgsFP3Z+XT9npGbRn5y49BSVlI21cv0EHOdZIdrwe++KUJytEr9OddIgeJiIHOiwTUcxEaK45VpDDhC/IYPhj0GY+jaYaMEhmNmJpyCYpGIooUyZOCsDkCYpE4ycEYJLCxHHjA4BtQceBhJMmhYTUO1XVO80GJrwNch7aDMgG4DsCTC2VuCEdpFY1rldffdUXyWwu6f70pz/5YBIQ5w8cOJCXkUCPFY500DYYCA+MPOrAhy/4UYXhhRQeq3NjHoJcAVAEM7M22P9SpuGB2jplJtbyd2RyQLtxfuEuPaicmrKJw/PQYhsQRQTJfJpsFYfqmWAWyXyBDkUwHVHUqU0IdkioPkCLKc1lRvJMsgnhxPcB0ZhsSnMgF3aagp1sZuP3AVrKRxp8V6QZF0ywiWPH0YQxYwOAbUHHWaQwSWJC6rUTHQi4LgtmWePHj+fpafg9rbH4bFyRDrJlyxYeRgDpQLhwpLvNZlaCWCDaH//4x5DAcQjcbNy4kV/PFYp0QDonMsvyfnppOg5+lO6m/OJMpS316mOmf8WwtBdPtFXf2SQswZiX0lqKTJK8ewiJuwhyVFVz0AMaLjdTz1LeDvNQaa9NIBdrL20irlU+GACCSSRRkndZi3GwQ5NMtJk/0GH6YjqyyNFF+GEMmInaVBRNZsLuAzGEbJOnKK2hzDYFJ20RRAhFNh9hQCImlx/jFbkE40aPCYC5z3e8Oh/EAEASO3zk8xFdfwd816Qgx0tZwJgxY2j06NH8e+N+jZTmCIYR8KAwaB6JdE5mpUmwm2++2Qf7dsx2QKAAybQyLT8QelY4Jm0iuuhbXgCEKlD7LaLBLARZkIIG4iBTAyYh/C0ENZBniFQoDC6DZNhelL+fsvals2m4dVMqm4XQWL4Jk4pQTCrLNOTxLx5o9kM0mAAEW7ZQfVeQrHjJIdRRxcCMC9Fq5kCw3y9zJpiYjSamK7IBMNNguk2xkSyAaAo+Yij4yeYnkWDcqNGu4DteAeOzgEkYO0DQiQKrfiEazgXBhGQAvo8aNYqHtuDntsais3FHOgjWVoF/Z5qYoTSdkE1gku2mm26iP/zhDwx8l/9lH8j8xRdfUNru3VShCCMBFtZerKkU8vEJbVXCZmAVSKXMwDqloRrq6lhrseZqOMBjXtUwBxUBC3LzKVP5XGm7dtGWzYpYGxSxlMYCsdgMxExki0w6c2M5LV/qJ9JShSXQVDALrTD9UtZgFixS+TM7EFUUIMvD0miKcDrwoTQZIFrNIhlg+mUzFJEAMRFN2AMLwFRlngFT4I8pTAK5oFkMgGDS6KVRj1UYZ2GsatxjFYFMjB45MhgjgiHkG4NzLJL4yGeR0YSvDnWsrlsTDMQyMWLECB+GDRvGbgnm0rWGxCXpIMiKeP311zmgAnLIOJ3dp4O2cyKdSTjg97//fQDMbc8++yyPR2EMBtkZ8PcqFWQQGRnxjUeO0fFjx+jgwYPsTMMsxcRcLKiLrHg8kPXr1weMc5ljXWYCrwDEYfJYn4ttybsCSewVIMPDTzZNMJDLjvkKZgAEEKJBmwnZpltaKxTRTJIBYjYC4hdJEMQMfEwwtJgQQUhnwqnRj1QkswPaBhg5bDiNsjBmxCjGaHWOaCcBiGgSGcBxZh0glXyibPkcMmQIDRo0iMk2YMAA+vbbb/lZt4bELekgyJB4/vnnW0w6EOvGG290BPbhWARvsOgMXvZeVVnJfpge44IZqHysLVvZD0SGBiZG2kllZsYDTlNIEHr3JfKCKFYWu2C+gqRICQLOsQANZicbxsnsmGsRzvTLhGizrGgjMM0lwQSmyejzjwz/TAIe4y0fDNpECGYSy2z8dgjBTEDjAMOHDqMRFkZaGKH2i2YSjBw+gkbZMNwqAxg6dCgNHjyYCYZPIVm/fv04o+mrr77i+Z/dunWjnj17tkrkEhLXpINAe2AmgpiYIJ0QTwIpIJsEUOympUmw3/72t/S73/3OESgT2gf1QVMh5QmRQBnLgsknRBIymTA1kxAGWkYg2wK0Dkw8A3gppkQIzeMEUsY8yydjv0yZinZIebOUNjOzLBiKXL5II3wxBdNsdCKYHSCb+EGszeAXmSSztMqYkdBC2gx0IpaQw4lYJkAOIQgwbPAQGm7DMLXffvzwIYqMDLVvkDpvkCKXRSzRYP3796e+ffuyJvvyyy+pR48e1L17d/rwww+ZbCAg2gMi660lcU86zF1CY0C2CrRdS0n3m9/8Jgi/+tWv2F9Ew4aWAol8oXVj7EoGiu2EAkxyCHGcII1/psJspXFMQAPJfqdzpXz4ZHaCmZDyZjoFQxS5dKTR74+5JZjADEyAaEw2MeEsojHZLO0CjSMEcyKTQDSOHdBAAEgCDB4wkIYMGBSAQRaRhEzAoP7qWAsD+/an/n36Ul+lwRAv+Oabb+jzzz/ndVkBkA2kgzZGBB3juLB6WvNtPSJxTzoIZurigUHTSUBFTEu3pIM2A8F+/etfB+GXv/wlm7Bo2CAVSARt4s+80I17Nho+oL5Di5iaxN64Q8GM/EnQwoQcJ+WCnFKXZLvPNuAzFw34ylKQunw+GkcY9cA0+2EKJsEEoUgGiH/GMLSaL8ABsg1TZBuq/C+FEQbRQCzTnDNhEsYEtI2J/n370QBBv/40UKG/tQ9aC6Yh0Pu776i30mBff9mLvvisJ33UrTt98MEH9NZbb9H777/PWg7uAfzzAwcOcACvLaRDkA6CF/OhZxJtFw3pQDhoORBMiAftJrjhhhvYp+NGrhqyCWn8M2aqBj1NEJx94QTxk9wCx9vLAHlQnwnM63IiscCpbPHR7FrMTjRHYllwCnwI0VijDdNBDhBt+GBl3onpZ2gt0UYmwdD47cQCeYRA0Eww/+yAtpJPAD7YZ599xm/zBbkwHvvee++xmdi3X182/VNTUzkAhoBYS5ddaK50GNJBkCoGE8A0MZtLOmi3X/ziF4yf/vSnvHwESGZvwKIhgOmTNWCeYUyKx6UcGrhAGno0sJeBDA+Q24SpwezHA/YyTdPRiWBORLNHAgHTFxMfTPtM2m8ChrP/pLTZwEFsBgKDbFpLSGYSy04uIRJWGMAzx9AOOl0AQQ0QC34XSPXmm29ypBuTorG+Kq4RUWQk0iMaffTo0XYjmJN0KNJBMPerS5cu7M+FIh0IJ8MBQDjS/fznP6ef/OQnPMsBGs2pEQvEB+JxKQviD7UGnEg3lf0vDV/2h9ER2I8HzDKFaHZT0dRcpgYTOEUWnYIdIxCwUFoNwY2hgwYz2QD4UzD7BioTsB98KUUukOo7mHzWp0ksAJoK5IK2go8FDQVtBXMQzxzEeu211+idd97h43BN8HEROcawDQiGjrmlKzDHWjoc6SAgHno4kK01SPfjH/+YHyg0h9lg7RAfyIRokNZCUJ0G0SXayJn5DgQTSFlOGi0UyYRo4Qhm+mMCIdggRTD4WP1796V+3ynN9e131OcbRbBvlOb6SpOqV69eDCEWtBJ8K5AIpHr55ZfppZde4vxbkA0kxHUiuIWo8q5duygvL4/zH7HOTryTK5R0SNJBMICNVySDbJKVgu920gnhQDb4byAcPk3z8vrrr+eHj0bsI4BqsEFQDdgO0SAmZN8EDBCHgVmO7xxVDyDXMckkuSIe4EQwE+a1iFYTzRZKi0l0UYhmjyhKoAOf4oexmai0WL/eIFlv6q2I9i20Vq+vqNcXX9Lnygz8VJmB3T7s5jMD//nPf3IHh+8wEaEBUSd+C4JYWHoPCelY9zKeTMLWlA5LOggySPAATeJB2wnpTH9OSGcnHHDDDTdwzwvzztfox/pz8wSmxggHOd4pp9CEWTYfryBlyHW4hUk0IZlJNEDIZddgQi6BRBPtgQ7xu2AainkIf0t8LAQvxL965ZVX2CyEmYjyYUUgkIHZ6UhCwIoBp0+f7rDaqiXSoUkHweI5eEcCgiZiYrohHcxKAIQD8dCYoCV8jV6Rwg6zMYeDkEpnxY8OCZOAfLyCrwyDRHbINZoQk9Guzcygh51kpploRhNNgiGoIaahmIQg19tvv80EA7AN+0FO1AdzEOus1NXVcRg+EYkVTjo86SAwNeETCOEETual6csBiFxiHxqb2XhlGokJs2ELpHGbwABxc4CxLl8ZBontQL2ivQRm/eKT2Qlmai/A1GDQXBLQgPZC+hMyM0AuRAXhY4F0KAf1I4CBfFMMIiN40dTU5JHLpVwTpINg3AX+Aohm+nVuSIfjpDFJI5ZBXxNmIxeYfpFAMjKihZku5VSXQIhlwvTJQDQhmWgwJ4KJ9gK54HMhoAHfFpoLpMNxMLmRc4ol+hLVHGxtuWZIBwHx0Fig8UKZl06kA0mhFUxtMVppHTvsDZ1hpTlFAifkKjjtMyHkMUlkh5iJoslEm4k/JiQTgonvhXsjpiE+MeaF/TgfwyVYSBXmemNjI0/WbOny4Z44yzVFOgjeHYZGZhIvHOl+9rOfcQAGDRgN2t7oTdgbP+DLwjBgkkIg5HDaFw4moaQMQPww0WAAfDD8dmgwBDAweAzNBYJBmyHggd+BgWNM3j1z5gxHCD3t1bZyzZEOAucdvg+yVtxoOhznRCjATgA7kIFhYpgCCGGHEMdpXziI5hKC4bsMNCPIAQ0m2RkgF77DZAQJ4XdhDhi0l4xtedL+ck2STgTz3UAoEA7jczJGB9LdcMMNrOUwMI4kamgAJ1KFIoqQSDIwTIAgpi8lpBHiCLBdAJJIWpTAjCCKBpP5XSAYghv4hH+GeXZIe8L4FjSYZxrGr1zTpINgGezOnTsz0aDlRNOZpMNcPRAMWkUg5MJ3IYwjrCx3E2LuCXFMgETwo+RTIMSS6CFMQQnPAyAaTEaUgalHeI8bxikx/eRaHUS+VuWaJx0EphUicyAZyAbiiT+HvEuswwKtZWoeIRW+i2YSMgG+bX0VuRQRgD69Fam+85PJJJJ8QlshDUqIhblcIBWuD4PJkrEBcxEdAaaeIPUJs5YRmvcI1vElIUgHQYOFn4dBdKR9gXBCOqzDAnJBMwmpTM0ksGsrQMiEPEEQCmQSIDoo411CLAwmY9wL44qIIsL/ArmgvSS/EEsDnjx50jMRr1FJGNKJIFMCJLvuuus4iALzEnPpQCRoJhBJvoNQAAglALEEIBZIheAFzD+MdYFIeL0zknaRwIuseEQQQWoZUN63bx8PKjc0NNCFCxe86GGCScKRDlJQUMAEAeF+9KMf8VJ/IJkQCeYfIJoKJqBJKmgqmIHILwSpsB3HI8KJ6TZI3EUQB34XsmWgZT2t5YlIQpIOcvHiRV6WAfPyEOFE0EJIBUJBSwHI64SPBW0GHw+DyPCz8GopmIJ4L8KxY8dYY3niiRtJWNKJYBoJCAXSwbREQAW+H2aRIyM+IyODM+K9xF1PWksSnnQQaD0vr9CTthKPdJ540sbikc6TDi3f4+/7q3RVAd87gnik86RDCpMNfxbhrly90mHcA490nnRIEdJd/f4KXVFoutLE5OsI4pHOkw4hQjKt2a5osintdlmRrenKJbpw6Zz63jFS5DzSeRL3oulmmZFCtqtNdOnKRbrQdJ7OK8Kdv3RWbfdI54knzRJQTD6ZbpbPpsl2mbXbRUW2sxdOMc4pwl28fMEzLz3xxBNn8UjniSdtLB7pPPGkjcUjnSeetLF4pPPEkzYWj3SeeNLG4pHOE0/aWDzSeeJJG4tHOk88aVMh+v/FMIFj4NvmWAAAAABJRU5ErkJggg==)
The invention is a collagen membrane functionalized with mannose for the treatment of chronic wounds. Due to its mannose coating, this membrane is able to induce the polarization of macrophages to an anti-inflammatory state, resulting in less overall inflammation during wound repair.
Stage of Development
In vitro data: Membrane synthesis and characterization studies have demonstrated the stability of the mannosylated membrane. In vitro studies indicated that the mannosylated membrane was able to successfully polarize macrophages to the M2 phenotype and reduce pro-inflammatory gene expression compared to standard collagen membranes.
In vivo data: Preliminary mouse experiments revealed that implanted mannose-coated collagen membranes showed significantly less inflammation compared to the regular collagen membranes and accelerated the wound healing response.
Competitive Landscape
Autologous skin grafts are currently considered the ‘gold standard’ for wound care in the clinic. Unfortunately, the availability of healthy donor tissue is often limited, resulting in the development of tissue‐engineered skin substitutes which offer alternative grafting approaches to wound care. Many of these products contain diverse biomaterials such as collagen, silicone, or nylon meshes but there are also some substitutes which are composed of cadaveric dermis. Additionally, there are many products that have been developed and applied for therapeutic applications to mimic the native skin architecture and its microenvironment properties, such as injectable cell suspensions, cell‐spray devices, or 3D scaffolds for skin tissue regeneration. Despite the promise of the tissue engineering approaches to date, there are still significant limitations in the cost of production and the potential risk of causing further healing impairments through triggering the onset of chronic inflammation. This biomimetic scaffold overcomes these limitations because it is specifically designed to reduce the inflammatory response and is manufactured using a cost-effective protocol.
Competitive Advantages
• Reduced inflammatory response during wound repair
• Faster healing time
• Implantable and/or topical applications
• Reproducible, scalable, and cost-effective manufacturing protocol