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Leukocyte-Derived Nanoparticles to Treat Triple-Negative Breast Cancer
This invention is an engineered biomimetic lipid-based nanoparticle (NP) functionalized with leukocyte membrane proteins (a.k.a. leukosomes) which are capable of targeting vascular inflammation. The ratio at which these leukocyte proteins are integrated within the NP shell dictates the biological behavior of the leukosomes. This particular formulation...
Published: 10/2/2024
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Inventor(s): Francesca Taraballi, Assaf Zinger
Keywords(s):
Category(s): Clinical Area > Cancer, Research Area > Cancer, Research Area > Nanomedicine, Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles
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Biomimetic Anti-Inflammatory Membrane for Chronic Wound Healing
The invention is a collagen membrane functionalized with mannose for the treatment of chronic wounds. Due to its mannose coating, this membrane is able to induce the polarization of macrophages to an anti-inflammatory state, resulting in less overall inflammation during wound repair. Stage of Development In vitro data: Membrane synthesis and characterization...
Published: 3/12/2024
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Inventor(s): Ennio Tasciotti, Francesca Taraballi
Keywords(s):
Category(s): Technology Classifications > Medical Device > Implantables, Clinical Area > Metabolic Disease, Inflammation, and Immunology, Research Area > Immunobiology and Inflammation, Research Area > Regenerative Medicine
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Implantable Patch for Controlled Drug Delivery
This invention is a biocompatible, biodegradable, multi-layer implantable patch for the controlled delivery of bioactive molecules. The biocompatibility of this patch facilitates the release of a precise amount of drug or other bioactive molecule to a specific region of the body over a desired period of time. The implantable patch has been utilized...
Published: 3/12/2024
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Inventor(s): Francesca Taraballi, Ennio Tasciotti, Federico Urzi
Keywords(s):
Category(s): Technology Classifications > Medical Device > Implantables, Technology Classifications > Therapeutic > Drug Delivery, Clinical Area > Pain, Clinical Area > Orthopedics and Sports Medicine, Research Area > Regenerative Medicine
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Periosteum-Like Scaffold for Bone Regeneration
This invention is an implantable, biomimetic scaffold which mimics the native structure of the human periosteum and is independently capable of regenerating bone tissue. This periosteum-like scaffold is composed of three layers comprising 1) a non-porous compact collagen layer, or a fibroblastic zone; 2) a collagen/elastin layer, which permits vascularization...
Published: 3/12/2024
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Inventor(s): Francesca Taraballi, Ennio Tasciotti, Silvia Minardi
Keywords(s):
Category(s): Technology Classifications > Medical Device > Implantables, Clinical Area > Orthopedics and Sports Medicine, Research Area > Regenerative Medicine
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