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LVAD Plug
Description of Invention
Left Ventricular Assist Devices (LVADs) are a promising alternative to cardiac transplantation in patients in patients with end stage heart failure. These devices are implanted as a bridge to transplant, bridge to recovery and as a destination therapy. The potential of cardiac recovery after using such mechanical support...
Published: 3/12/2024
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Inventor(s): Neal Waxali
Keywords(s):
Category(s): Clinical Area, Clinical Area > Cardiovascular, Technology Classifications > Medical Device
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Modulating the AIBP-CAV1-VEGFR3 axis to treat lymphatic disorders
This invention is a method of promoting lymphangiogenesis in order to treat lymphatic disorders, namely lymphedema and Alzheimer’s disease (AD). VEGFC-induced VEGFR3 signaling is the major driver of lymphangiogenesis, however the distinct molecular mechanisms determining how VEGFR3 signaling controls lymphatic endothelial cell (LEC) fate remains...
Published: 3/12/2024
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Inventor(s): Longhou Fang, Jun-dae Kim
Keywords(s):
Category(s): Clinical Area > Metabolic Disease, Inflammation, and Immunology, Clinical Area > Neurology, Clinical Area > Cardiovascular, Research Area > Heart and Vascular, Research Area > Immunobiology and Inflammation, Research Area > Neurology and Neurosurgery, Technology Classifications > Therapeutic > Cell and Gene Therapies, Technology Classifications > Therapeutic > Small Molecules, Technology Classifications > Therapeutic > Biologics
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Nanovaccine for Heart Failure
This Invention is a vaccine therapy using a combination of a nanoparticle delivery and human peptides to immunize against the development of heart failure or cardiac disease.Stage of Development In vivo data: A non-ischemic heart failure mouse model was used in which mice are vaccinated before the initiation of the heart failure protocol. These mice...
Published: 3/12/2024
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Inventor(s): Haifa Shen, Guillermo Torre, Keith Youker
Keywords(s):
Category(s): Clinical Area > Cardiovascular, Research Area > Nanomedicine, Technology Classifications > Therapeutic > Vaccines
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Apoliprotein-B Functionalized Nanoparticles for Targeted Delivery to Atherosclerotic Plaques
This invention is a proteolipid nanoparticle platform functionalized with apolipoprotein B-100 for localized delivery of therapeutic compounds to atherosclerotic plaques, termed aposomes. Apolipoprotein B-100 is a crucial functional and structural component of low density lipoproteins (LDLs) and therefore plays a critical role in cholesterol transport...
Published: 3/12/2024
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Inventor(s): Ennio Tasciotti, Roberto Molinaro, Christian Boada Sandoval
Keywords(s):
Category(s): Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles, Clinical Area > Cancer, Clinical Area > Metabolic Disease, Inflammation, and Immunology, Research Area > Heart and Vascular, Research Area > Nanomedicine, Clinical Area > Cardiovascular
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