Search Results - technology+classifications+%3e+therapeutic+%3e+nanovesicles

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Leukocyte-Derived Nanoparticles to Treat Triple-Negative Breast Cancer
This invention is an engineered biomimetic lipid-based nanoparticle (NP) functionalized with leukocyte membrane proteins (a.k.a. leukosomes) which are capable of targeting vascular inflammation. The ratio at which these leukocyte proteins are integrated within the NP shell dictates the biological behavior of the leukosomes. This particular formulation...
Published: 3/11/2021   |   Inventor(s): Francesca Taraballi, Assaf Zinger
Keywords(s):  
Category(s): Clinical Area > Cancer, Research Area > Cancer, Research Area > Nanomedicine, Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles
Ponatinib-Encapsulated Biomimetic Nanoparticle to Treat Osteosarcoma
This invention is a novel formulation of ponatinib which allows for targeted drug delivery to osteosarcoma tumors. This formulation utilizes a biomimetic lipid-based nanoparticle (NP) embedded with leukocyte membrane proteins (a.k.a. leukosomes). Previous iterations of leukosomes have demonstrated improved targeting of inflamed endothelium. Due to the...
Published: 7/23/2020   |   Inventor(s): Francesca Taraballi, Assaf Zinger, Ennio Tasciotti, Tomoyuki Naoi, Gherardo Baudo
Keywords(s):  
Category(s): Clinical Area > Cancer, Research Area > Cancer, Research Area > Nanomedicine, Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles, Technology Classifications > Therapeutic > Small Molecules
Neural/Glial Cell-Derived Nanoparticles to Restore Neural Function in Alzheimer’s Disease
This invention is an engineered biomimetic nanoparticle (NP) that integrates neural or glial cell membrane proteins into lipid-based nanoparticles (a.k.a. neurosomes). The integration of these neural/glial cell proteins within the NP shell enable precise targeting to treat a variety of neurological disorders resulting from trauma, neurodegeneration,...
Published: 6/1/2020   |   Inventor(s): Robert Krencik, Assaf Zinger, Ennio Tasciotti, Caroline Cvetkovic
Keywords(s):  
Category(s): Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles, Clinical Area > Neurology, Research Area > Neurology and Neurosurgery, Research Area > Nanomedicine
Apoliprotein-B Functionalized Nanoparticles for Targeted Delivery to Atherosclerotic Plaques
This invention is a proteolipid nanoparticle platform functionalized with apolipoprotein B-100 for localized delivery of therapeutic compounds to atherosclerotic plaques, termed aposomes. Apolipoprotein B-100 is a crucial functional and structural component of low density lipoproteins (LDLs) and therefore plays a critical role in cholesterol transport...
Published: 5/29/2020   |   Inventor(s): Ennio Tasciotti, Roberto Molinaro, Christian Boada Sandoval
Keywords(s):  
Category(s): Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles, Clinical Area > Cancer, Clinical Area > Metabolic Disease, Inflammation, and Immunology, Research Area > Heart and Vascular, Research Area > Nanomedicine, Clinical Area > Cardiovascular