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Leukocyte-Derived Nanoparticles to Treat Triple-Negative Breast Cancer
This invention is an engineered biomimetic lipid-based nanoparticle (NP) functionalized with leukocyte membrane proteins (a.k.a. leukosomes) which are capable of targeting vascular inflammation. The ratio at which these leukocyte proteins are integrated within the NP shell dictates the biological behavior of the leukosomes. This particular formulation...
Published: 10/2/2024
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Inventor(s): Francesca Taraballi, Assaf Zinger
Keywords(s):
Category(s): Clinical Area > Cancer, Research Area > Cancer, Research Area > Nanomedicine, Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles
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Nanovaccine for Heart Failure
This Invention is a vaccine therapy using a combination of a nanoparticle delivery and human peptides to immunize against the development of heart failure or cardiac disease.Stage of Development In vivo data: A non-ischemic heart failure mouse model was used in which mice are vaccinated before the initiation of the heart failure protocol. These mice...
Published: 10/1/2024
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Inventor(s): Haifa Shen, Guillermo Torre, Keith Youker
Keywords(s):
Category(s): Clinical Area > Cardiovascular, Research Area > Nanomedicine, Technology Classifications > Therapeutic > Vaccines
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Neural/Glial Cell-Derived Nanoparticles to Restore Neural Function in Alzheimer’s Disease
This invention is an engineered biomimetic nanoparticle (NP) that integrates neural or glial cell membrane proteins into lipid-based nanoparticles (a.k.a. neurosomes). The integration of these neural/glial cell proteins within the NP shell enable precise targeting to treat a variety of neurological disorders resulting from trauma, neurodegeneration,...
Published: 10/8/2024
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Inventor(s): Robert Krencik, Assaf Zinger, Ennio Tasciotti, Caroline Cvetkovic
Keywords(s):
Category(s): Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles, Clinical Area > Neurology, Research Area > Neurology and Neurosurgery, Research Area > Nanomedicine
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Apoliprotein-B Functionalized Nanoparticles for Targeted Delivery to Atherosclerotic Plaques
This invention is a proteolipid nanoparticle platform functionalized with apolipoprotein B-100 for localized delivery of therapeutic compounds to atherosclerotic plaques, termed aposomes. Apolipoprotein B-100 is a crucial functional and structural component of low density lipoproteins (LDLs) and therefore plays a critical role in cholesterol transport...
Published: 3/12/2024
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Inventor(s): Ennio Tasciotti, Roberto Molinaro, Christian Boada Sandoval
Keywords(s):
Category(s): Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles, Clinical Area > Cancer, Clinical Area > Metabolic Disease, Inflammation, and Immunology, Research Area > Heart and Vascular, Research Area > Nanomedicine, Clinical Area > Cardiovascular
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