Search Results - research+area+%3e+heart+and+vascular

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Modulating the AIBP-CAV1-VEGFR3 axis to treat lymphatic disorders

This invention is a method of promoting lymphangiogenesis in order to treat lymphatic disorders, namely lymphedema and Alzheimer’s disease (AD). VEGFC-induced VEGFR3 signaling is the major driver of lymphangiogenesis, however the distinct molecular mechanisms determining how VEGFR3 signaling controls lymphatic endothelial cell (LEC) fate remains...

Published: 3/12/2024 | Inventor(s): Longhou Fang, Jun-dae Kim

Keywords(s):

Category(s): Clinical Area > Metabolic Disease, Inflammation, and Immunology, Clinical Area > Neurology, Clinical Area > Cardiovascular, Research Area > Heart and Vascular, Research Area > Immunobiology and Inflammation, Research Area > Neurology and Neurosurgery, Technology Classifications > Therapeutic > Cell and Gene Therapies, Technology Classifications > Therapeutic > Small Molecules, Technology Classifications > Therapeutic > Biologics

Apoliprotein-B Functionalized Nanoparticles for Targeted Delivery to Atherosclerotic Plaques

This invention is a proteolipid nanoparticle platform functionalized with apolipoprotein B-100 for localized delivery of therapeutic compounds to atherosclerotic plaques, termed aposomes. Apolipoprotein B-100 is a crucial functional and structural component of low density lipoproteins (LDLs) and therefore plays a critical role in cholesterol transport...

Published: 3/12/2024 | Inventor(s): Ennio Tasciotti, Roberto Molinaro, Christian Boada Sandoval

Keywords(s):

Category(s): Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles, Clinical Area > Cancer, Clinical Area > Metabolic Disease, Inflammation, and Immunology, Research Area > Heart and Vascular, Research Area > Nanomedicine, Clinical Area > Cardiovascular