Search Results - clinical+area+%3e+cardiovascular

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Nanovaccine for Heart Failure
This Invention is a vaccine therapy using a combination of a nanoparticle delivery and human peptides to immunize against the development of heart failure or cardiac disease.Stage of Development In vivo data: A non-ischemic heart failure mouse model was used in which mice are vaccinated before the initiation of the heart failure protocol. These mice...
Published: 7/10/2020   |   Inventor(s): Haifa Shen, Guillermo Torre, Keith Youker
Category(s): Clinical Area > Cardiovascular, Research Area > Nanomedicine, Technology Classifications > Therapeutic > Vaccines
Thermo-sensitive Hydrogel for Left Atrial Appendage Occlusion
This invention is nanostructured radiopaque, biomimetic, anti-coagulant, and thermo-sensitive hydrogel which is injected directly into the left atrial appendage (LAA) to occlude the space thereby preventing clot formation and subsequent atrial fibrillation and stroke. The thermo-sensitive properties of this hydrogel enable it to be delivered percutaneously...
Published: 5/29/2020   |   Inventor(s): Miguel Valderrabano, Ennio Tasciotti, Francesca Taraballi, Cristina Lupo
Category(s): Technology Classifications > Medical Device > Implantables, Research Area > Heart and Vascular, Clinical Area > Cardiovascular
Apoliprotein-B Functionalized Nanoparticles for Targeted Delivery to Atherosclerotic Plaques
This invention is a proteolipid nanoparticle platform functionalized with apolipoprotein B-100 for localized delivery of therapeutic compounds to atherosclerotic plaques, termed aposomes. Apolipoprotein B-100 is a crucial functional and structural component of low density lipoproteins (LDLs) and therefore plays a critical role in cholesterol transport...
Published: 5/29/2020   |   Inventor(s): Ennio Tasciotti, Roberto Molinaro, Christian Boada Sandoval
Category(s): Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles, Clinical Area > Cancer, Clinical Area > Metabolic Disease, Inflammation, and Immunology, Research Area > Heart and Vascular, Research Area > Nanomedicine, Clinical Area > Cardiovascular