Search Results - technology+classifications+%3e+therapeutic+%3e+small+molecules

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Beclin 2-Functionalized Therapies for Treatment of Neurodegenerative Disease and Cancer
This invention identified that Beclin 2 functions as a negative regulator of the ERK1/2 signaling, NF-κB signaling, and inflammasome activation. Furthermore, these studies demonstrated that Beclin 2 targets key signalling kinases for degradation through an ATG9A-dependent autophagic pathway. These new findings have uncovered an important role...
Published: 9/28/2020   |   Inventor(s): Rongfu Wang, Helen (Yicheng) Wang, Motao Zhu
Keywords(s):  
Category(s): Clinical Area > Cancer, Clinical Area > Neurology, Research Area > Cancer, Research Area > Immunobiology and Inflammation, Research Area > Neurology and Neurosurgery, Technology Classifications > Therapeutic > Biologics, Technology Classifications > Therapeutic > Small Molecules, Technology Classifications > Therapeutic > Immunotherapy
Ponatinib-Encapsulated Biomimetic Nanoparticle to Treat Osteosarcoma
This invention is a novel formulation of ponatinib which allows for targeted drug delivery to osteosarcoma tumors. This formulation utilizes a biomimetic lipid-based nanoparticle (NP) embedded with leukocyte membrane proteins (a.k.a. leukosomes). Previous iterations of leukosomes have demonstrated improved targeting of inflamed endothelium. Due to the...
Published: 7/23/2020   |   Inventor(s): Francesca Taraballi, Assaf Zinger, Ennio Tasciotti, Tomoyuki Naoi, Gherardo Baudo
Keywords(s):  
Category(s): Clinical Area > Cancer, Research Area > Cancer, Research Area > Nanomedicine, Technology Classifications > Therapeutic > Drug Delivery, Technology Classifications > Therapeutic > Nanovesicles, Technology Classifications > Therapeutic > Small Molecules
Glycolytic Modulators for Therapeutic Regulation of Cell Fate
This invention is a glycolysis enhancement strategy using glycolytic modulators to improve cell fate transitions. Applied topically, systemically, or in combination with a biocompatible scaffold, the glycolytic enhancers are expected to improve wound healing, vascularity, and tissue regeneration as well as reduce fibrosis. In another application, a...
Published: 6/1/2020   |   Inventor(s): John Cooke, Li Lai
Keywords(s):  
Category(s): Technology Classifications > Therapeutic > Small Molecules, Research Area > Regenerative Medicine, Clinical Area > Cancer, Research Area > Cancer
SREBP2 Inhibitors for Treating T-Cell Acute Lymphoblastic Leukemia
This invention is a method of inhibiting sterol regulatory element-binding protein 2 (SREBP2) in order to treat, prevent, reverse, and/or ameliorate conditions associated with an improper number of hematopoietic stem and progenitor cells (HSPCs). SREBP22 is traditionally known as a transcription factor that plays a role in cholesterol homeostasis. However,...
Published: 6/1/2020   |   Inventor(s): Longhou Fang, Qilin Gu
Keywords(s):  
Category(s): Technology Classifications > Therapeutic > Small Molecules, Technology Classifications > Therapeutic > Cell and Gene Therapies, Clinical Area > Cancer, Research Area > Cancer