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SARS-CoV-2 Antibodies to Treat or Diagnose COVID-19

This invention includes multiple high affinity, human antibodies that selectively target the SARS-CoV-2 virus which is responsible for COVID-19. Each antibody was identified by screening an internally developed human single chain variable fragment (scFv) library against different components of the SARS-CoV-2 virus particle. Successful screening protocols...

Published: 5/6/2024 | Inventor(s): Xian Li, Xiaohua Lou

Keywords(s):

Category(s): Clinical Area > Infectious Disease, Research Area > Infectious Diseases and Pathology, Technology Classifications > Research Tool > Antibodies, Technology Classifications > Therapeutic > Biologics, Technology Classifications > Therapeutic > Antibodies

IRF4-Targeted Therapies for Cancer, Transplant Rejection, and Autoimmune Disorders

This invention is a method of depleting or over-expressing the transcription factor, interferon regulatory factor 4 (IRF4), in T cells as therapeutic strategy for conditions which are highly regulated by the immune system. The inventors have established that IRF4 represses PD-1, Helios, and other molecules associated with T cell function, representing...

Published: 10/8/2024 | Inventor(s): Wenhao Chen, Xian Li

Keywords(s):

Category(s): Technology Classifications > Therapeutic > Cell and Gene Therapies, Clinical Area > Transplantation, Clinical Area > Cancer, Clinical Area > Metabolic Disease, Inflammation, and Immunology, Research Area > Cancer, Research Area > Immunobiology and Inflammation