Latest technologies from The Methodist Hospital Research Institutehttp://tmhri.technologypublisher.comBe the first to know about the latest inventions and technologies available from Houston Methodisten-USSat, 11 Apr 2026 12:23:32 GMTWed, 02 Apr 2025 11:08:11 GMThttp://blogs.law.harvard.edu/tech/rsssraghuraman@houstonmethodist.orgCopyright 2026, The Methodist Hospital Research InstituteMethod for Vascular Regeneration and Wound TreatmentOTT202123https://tmhri.technologypublisher.com/technology/56736Wed, 02 Apr 2025 11:08:11 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/56736Systems and Methods for Whole Brain Net Water Uptake Imaging using Non-Contrast CT ScansOTT202216https://tmhri.technologypublisher.com/technology/56735Wed, 02 Apr 2025 11:03:47 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/56735A multimedia artificial intelligence method of deep learning for detection of stroke using patient facial video and voiceOTT202040https://tmhri.technologypublisher.com/technology/56728Tue, 01 Apr 2025 13:30:56 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/56728A method of computed tomography (CT) noise reduction using different CT scans from the same person and convolutional neural networkOTT202009https://tmhri.technologypublisher.com/technology/56727Software Description of Invention Computed tomography (CT) is commonly used to image different parts of the body with or without contrast injection. Its image quality is directly related to the amount of ionizing radiation dose. It is especially limited in CT of the brain where increased radiation is known to cause damage and hamper brain development. Therefore, brain CT is known for excessive image noise and low image contrast. Brain CT can be done quickly for diagnosis of different neurological conditions (stroke, hemorrhage, and it is especially useful in emergency settings to identify ...Tue, 01 Apr 2025 12:12:01 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/56727IRF4-Engineered T Cells Induce T Cell Function As a Treatment Strategy for Solid TumorsOTT201714https://tmhri.technologypublisher.com/technology/56601Wed, 26 Mar 2025 14:58:51 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/56601Neural/Glial Cell-Derived Nanoparticles to Restore Neural Function in Alzheimer’s DiseaseOTT201935https://tmhri.technologypublisher.com/technology/56600Wed, 26 Mar 2025 14:54:33 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/56600LVAD PlugOTT202036https://tmhri.technologypublisher.com/technology/53236Wed, 07 Feb 2024 08:37:07 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/53236Modulating the AIBP-CAV1-VEGFR3 axis to treat lymphatic disordersOTT202021https://tmhri.technologypublisher.com/technology/44676Tue, 17 Aug 2021 07:15:18 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/44676Leukocyte-Derived Nanoparticles to Treat Triple-Negative Breast CancerOTT202106https://tmhri.technologypublisher.com/technology/43179Thu, 11 Mar 2021 12:16:00 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/43179Specific PD-1 DNA Aptamers as Immunotherapeutic Agents in the Treatment of CancersOTT201522https://tmhri.technologypublisher.com/technology/41447Mon, 31 Aug 2020 15:23:06 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/41447 Aptamer-Based Assay for Rapid Detection of Mycoplasma-infected cellsOTT201908https://tmhri.technologypublisher.com/technology/40855Fri, 10 Jul 2020 11:42:33 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/40855Microfibrillar-associated Protein 5 (MFAP5)-Specific Monoclonal Antibodies as Therapeutic Agents in Ovarian and Pancreatic CancersOTT201835https://tmhri.technologypublisher.com/technology/40854Fri, 10 Jul 2020 11:37:30 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/40854Nanovaccine for Heart FailureOTT201812https://tmhri.technologypublisher.com/technology/40853Fri, 10 Jul 2020 11:33:05 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/40853Aptamer-engineered Natural Killer Cells for Adaptive ImmunotherapyOTT201810https://tmhri.technologypublisher.com/technology/40852Fri, 10 Jul 2020 11:25:50 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/40852A DNAzyme that targets the CAG repeat RNA in polyglutamine diseasesOTT201823https://tmhri.technologypublisher.com/technology/40810Wed, 08 Jul 2020 08:18:50 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/40810Biomimetic Anti-Inflammatory Membrane for Chronic Wound HealingOTT201919https://tmhri.technologypublisher.com/technology/40106Mon, 01 Jun 2020 07:23:02 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/40106 Glycolytic Modulators for Therapeutic Regulation of Cell FateOTT201829https://tmhri.technologypublisher.com/technology/40105Mon, 01 Jun 2020 07:22:27 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/40105SREBP2 Inhibitors for Treating T-Cell Acute Lymphoblastic LeukemiaOTT201736https://tmhri.technologypublisher.com/technology/40104Mon, 01 Jun 2020 07:22:00 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/40104Implantable Patch for Controlled Drug DeliveryOTT201505https://tmhri.technologypublisher.com/technology/40102Mon, 01 Jun 2020 07:21:21 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/40102Apoliprotein-B Functionalized Nanoparticles for Targeted Delivery to Atherosclerotic PlaquesOTT201719https://tmhri.technologypublisher.com/technology/40069This invention is a proteolipid nanoparticle platform functionalized with apolipoprotein B-100 for localized delivery of therapeutic compounds to atherosclerotic plaques, termed aposomes. Apolipoprotein B-100 is a crucial functional and structural component of low density lipoproteins (LDLs) and therefore plays a critical role in cholesterol transport and atherosclerosis pathophysiology, making it an attractive candidate for targeted drug delivery to atherosclerotic plaques. The aposome platform described herein incorporates plasma derived apolipoprotein B onto the surface of liposomes, allowi...Fri, 29 May 2020 12:09:38 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/40069Perme ICU Mobility Scoring System for Evaluating the Mobility Status of Patients in the ICUOTT201006https://tmhri.technologypublisher.com/technology/40068Fri, 29 May 2020 11:33:28 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/40068Periosteum-Like Scaffold for Bone RegenerationOTT201420https://tmhri.technologypublisher.com/technology/40056This invention is an implantable, biomimetic scaffold which mimics the native structure of the human periosteum and is independently capable of regenerating bone tissue. This periosteum-like scaffold is composed of three layers comprising 1) a non-porous compact collagen layer, or a fibroblastic zone; 2) a collagen/elastin layer, which permits vascularization and recapitulates the elastic features of periosteum; and 3) a biomineralized collagen layer, which preferably exploits the presence of hydroxyapatite to induce bone formation. In total, these properties promote the formation and growth o...Thu, 28 May 2020 09:51:07 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/40056PSMA-Targeted CAR-T Therapy for Castration-Resistant Prostate CancerOTT201918https://tmhri.technologypublisher.com/technology/40055Thu, 28 May 2020 09:47:52 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/40055Multivalent ligands targeting VEGFRMKT201408https://tmhri.technologypublisher.com/technology/15537Wed, 16 Jul 2014 12:25:22 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/15537Sustained delivery of doxorubicin to tumorsMKT201205https://tmhri.technologypublisher.com/technology/13201Wed, 31 Jul 2013 12:48:18 GMTsraghuraman@houstonmethodist.orghttps://tmhri.technologypublisher.com/technology/13201