Search Results - Therapeutic

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ssDNA Aptamer-Drug Conjugates for Targeted Cancer Treatment
Invention The invention is a CD38 specific ssDNA aptamer–chemotherapeutic drug conjugate and a CD117 specific ssDNA aptamer–chemotherapeutic drug conjugate for targeted therapy of cancers overexpressing CD38, as in the case of Multiple Myeloma (MM) or CD117, in the case of Acute Myeloid Leukemia (AML). Background For targeted therapy, ...
Published: 6/12/2015   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutic
Triple Negative Breast Cancer Combination Therapy
Invention The Invention is a combination therapy for the treatment of highly aggressive and lethal Triple Negative Breast Cancer (TNBC). TNBC is involved in tumor resistance, progression and subsequent metastasis. A novel combined treatment resulted in reduced TNBC growth, cancer stem cell growth, and cancer cell migration. Furthermore, the comb...
Published: 12/17/2014   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutic
Discoidal Polymeric Nanoconstructs for Cancer Theranostics
Invention The invention is discoidal, polymeric nanoconstructs with superior properties and a method of manufacturing the particles with improved control of particle size, shape, surface properties and mechanical stiffness. The particles are useful for systemic delivery of one or more imaging agents and / or therapeutic agents to particular cell ty...
Published: 10/23/2014   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutic, Diagnostic, Imaging
Targeted PDT Agent for Improved Pancreatic Cancer Treatment
Invention The invention is a targeted drug designed to selectively kill cathepsin E (Cath E)-positive pancreatic ductal adenocarcinoma (PDAC) cells, but not normal cells. Cath E expression is upregulated in PDAC cells approximately 117-fold, when compared with normal pancreatic cells. 5-ALA is known for its suitability as a tumor-imaging agent and...
Published: 9/26/2014   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutic
Targeted Diagnosis and Treatment of Cancer using Highly Selective Cathepsin E Substrates
Invention The invention is a peptide sequence that is highly selectively cleaved by Cathepsin E. It can be used to detect cancer non-invasively or can be utilized in a nanoparticle for targeted drug delivery. Background Cathepsin E (Cath E) and Cathepsin D (Cath D) are members of the aspartic proteolytic enzymes family but unlike the relatively ...
Published: 9/26/2014   |   Inventor(s):  
Keywords(s): Imaging
Category(s): Diagnostic, Therapeutic
Multivalent ligands targeting VEGFR
Invention The invention consists of novel compounds for angiogenesis-targeted therapy and imaging particularly for diseases such as cancer where increased angiogenesis is deleterious. The compounds target the VEGF receptor (VEGFR) with 100-fold improvement in binding affinity, higher specificity and tumor cell uptake and improved blood clearance. T...
Published: 7/16/2014   |   Inventor(s):  
Keywords(s):  
Category(s): Imaging, Therapeutic
Novel Mitochondrial Targeted Glioblastoma Drugs
Invention The invention is a blood/ brain barrier permeable prodrugs which are selectively activated by an enzyme that is highly upregulated in glioma cells. The activation selectively targets the drug “warhead” to the mitochondria of glioma cells at high concentration and damages or destroys the mitochondrial DNA. Cancer cells includin...
Published: 3/28/2014   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutic
Highly Efficient Thermal Ablation of Cancer
SEM images of mesoporous silicon particles loaded with gold nanoparticles Invention The invention consists of gold nanoparticles packaged in porous silicon particles. The particles are delivered to the tumor site and then heated using a near infrared laser. These particles generate heat 3 times faster than gold nanoparticles alone and the result i...
Published: 7/31/2013   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutic
Sustained delivery of doxorubicin to tumors
Invention The invention provides an efficient and sustained release of doxorubicin in a tumor. The invention is a polymer linked to doxorubicin, packaged inside a porous particle. High local concentrations of doxorubicin can be achieved at the site of the tumor which avoids the toxic effects of the drug on other tissues. Other cancer drugs may be a...
Published: 7/31/2013   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutic
Network-based Signatures for Drug Repositioning
Invention The invention is a new computational systems biology strategy that facilitates the integration of a variety of biological information to identify a network-based signature and incorporate a comprehensive signaling map to identify FDA-approved drug candidates for repositioning, combinational therapy and disease management strategies. This...
Published: 7/31/2013   |   Inventor(s):  
Keywords(s): Software
Category(s): Therapeutic
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