Search Results - Imaging

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Discoidal Polymeric Nanoconstructs for Cancer Theranostics
Invention The invention is discoidal, polymeric nanoconstructs with superior properties and a method of manufacturing the particles with improved control of particle size, shape, surface properties and mechanical stiffness. The particles are useful for systemic delivery of one or more imaging agents and / or therapeutic agents to particular cell ty...
Published: 10/23/2014   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutic, Diagnostic, Imaging
Multivalent ligands targeting VEGFR
Invention The invention consists of novel compounds for angiogenesis-targeted therapy and imaging particularly for diseases such as cancer where increased angiogenesis is deleterious. The compounds target the VEGF receptor (VEGFR) with 100-fold improvement in binding affinity, higher specificity and tumor cell uptake and improved blood clearance. T...
Published: 7/16/2014   |   Inventor(s):  
Keywords(s):  
Category(s): Imaging, Therapeutic
pH sensitive dye for tumor detection
Invention The invention is a pH-sensitive near-infrared fluorescent dye that can detect tumors by targeting the acidic tumor microenvironment. The dye is non-fluorescent in normal tissues but fluoresces when taken up by neoplastic lesions. The pH-triggered activation of the dye permits a high signal to background ratio so that lesion as small as 1m...
Published: 7/15/2014   |   Inventor(s):  
Keywords(s):  
Category(s): Diagnostic, Imaging
Highly Potent Fluorescent Multivalent Integrin Antagonists for Targeted Therapy and Imaging
In vivo fluorescence imaging of live U-87 xenograft tumor-bearing mice 24 hours post intravenously administered unconjugated Cy5.5 vs. bivalent IA-Cy5.5. Invention This invention presents a new class of fluorescent integrin ανβ3 antagonists that display higher binding affinity, specificity, and inherent stability than commercially...
Published: 7/31/2013   |   Inventor(s):  
Keywords(s): Therapeutic
Category(s): Imaging
Real-Time Multimodality Image Guidance System for On-the-Spot Lung Cancer Diagnosis and Treatment
Invention The invention is a minimally invasive, real-time multi-modality image guidance system for diagnosis and immediate treatment of lung cancer. Background Lung cancer is the most common cause of cancer-related death resulting in over 210,000 new lung cancers and about 160,000 deaths in the United States in 2007. The key to improving long t...
Published: 7/31/2013   |   Inventor(s):  
Keywords(s): Medical Device
Category(s): Diagnostic, Therapeutic, Imaging
Improved Diagnostic, Monitoring and Prognostic Tool for Cardiovascular Disease
Invention The invention is a fast, readily available, non-invasive, in-vivo technique that automates and quantifies local wall motion. It provides a method of identifying wall regions with high mobility that are prone to rupture. The invention is useful for the diagnosis and monitoring of cardiovascular diseases such as cerebral, thoracic and aorti...
Published: 7/31/2013   |   Inventor(s):  
Keywords(s): Diagnostic, Software
Category(s): Imaging
Enhanced Visualization of the Flow of White Matter in the Brain and Spinal Cord
Invention The invention is a system and method for more accurate determination and 3-D visualization of the direction of white matter fiber bundles in the brain and spinal cord through processing of MRI images with a novel diffusion anisotropy method. This approach does not rely on the Eigenvector and Eigenvalues calculations employed by existing ...
Published: 7/31/2013   |   Inventor(s):  
Keywords(s): Diagnostic, Software
Category(s): Imaging
Low Cost Device for Computer-Enhanced Targeted Radiation Therapy
Invention The invention provides clinicians an inexpensive and effective way to establish the optimal position and orientation of the treatment area of a patient’s body, then to incorporate that information into a computerized model for treatment planning, and to duplicate the position precisely in any treatment setting. Background Isolat...
Published: 7/31/2013   |   Inventor(s):  
Keywords(s): Medical Device
Category(s): Imaging
Low Cost Device for Accurate Digital Dental Modeling
InventionThis invention provides dental professionals with a simple, inexpensive and effective way to digitally establish the correct orientation of the jaw. This information can then be incorporated into digital dental models for the diagnosis and treatment of various dental conditions. The invention has utility in the fields of orthodontics, pros...
Published: 7/31/2013   |   Inventor(s):  
Keywords(s): Imaging, Medical Device
Category(s): Imaging