Search Results - Diagnostic

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Serum Biomarker for Breast Cancer Diagnosis and Prognosis
Invention The invention is a plasma biomarker for breast cancer, the levels of which correlate closely with disease stage. The marker can be used for less invasive diagnosis of breast cancer and to monitor treatment efficacy. Background Breast Cancer is the 2nd leading cause of death for women in the US with 150,000 new cases and 44,000 deaths per...
Published: 6/3/2015   |   Inventor(s):  
Keywords(s):  
Category(s): Diagnostic
Discoidal Polymeric Nanoconstructs for Cancer Theranostics
Invention The invention is discoidal, polymeric nanoconstructs with superior properties and a method of manufacturing the particles with improved control of particle size, shape, surface properties and mechanical stiffness. The particles are useful for systemic delivery of one or more imaging agents and / or therapeutic agents to particular cell ty...
Published: 10/23/2014   |   Inventor(s):  
Keywords(s):  
Category(s): Therapeutic, Diagnostic, Imaging
Targeted Diagnosis and Treatment of Cancer using Highly Selective Cathepsin E Substrates
Invention The invention is a peptide sequence that is highly selectively cleaved by Cathepsin E. It can be used to detect cancer non-invasively or can be utilized in a nanoparticle for targeted drug delivery. Background Cathepsin E (Cath E) and Cathepsin D (Cath D) are members of the aspartic proteolytic enzymes family but unlike the relatively ...
Published: 9/26/2014   |   Inventor(s):  
Keywords(s): Imaging
Category(s): Diagnostic, Therapeutic
Improved method of mapping cardiac arrhythmias
Invention The invention is an algorithm for mapping complex cardiac arrhythmias without having to obtain simultaneously recorded signals from the large surface area of the cardiac tissue. The algorithm can be used to create a high resolution map that allows for the localization of the sources of periodic activity that may underlie complex cardiac a...
Published: 7/16/2014   |   Inventor(s):  
Keywords(s):  
Category(s): Diagnostic
pH sensitive dye for tumor detection
Invention The invention is a pH-sensitive near-infrared fluorescent dye that can detect tumors by targeting the acidic tumor microenvironment. The dye is non-fluorescent in normal tissues but fluoresces when taken up by neoplastic lesions. The pH-triggered activation of the dye permits a high signal to background ratio so that lesion as small as 1m...
Published: 7/15/2014   |   Inventor(s):  
Keywords(s):  
Category(s): Diagnostic, Imaging
ODOSA - One-Drop, One-Step Assay for Circulating Tumor Cell Detection
Invention The invention is a cell-specific, intracellularly-activated, one step assay for the detection of circulating tumor cells (CTC) in a single drop of blood. The invention is based on cell-specific aptamers linked to fluorophores and quenchers. Lysosomal degradation leads to release of quenching and switches on a strong fluorescent signal in ...
Published: 7/31/2013   |   Inventor(s):  
Keywords(s):  
Category(s): Diagnostic
V-Chip
Invention The invention is portable glass diagnostic chip, activated by hand sliding two plates to open and close microfluidic channels. Assay results are based on ELISA technology and are visualized by the reaction of catalase and H2O2 creating O2 gas which moves a red dye through the channels to a distance proportional to the concentration of the...
Published: 7/31/2013   |   Inventor(s):  
Keywords(s):  
Category(s): Diagnostic, Research Tool
Prognostic Assay for Brain Metastasis of Breast Cancer and Methods to Identify Therapeutics
Invention The invention is a validated 31 protein panel to predict the likelihood of a breast cancer metastasizing to the brain and its use would allow personalization of breast cancer treatment. In addition, the core intervention signaling network developed can be used to identify new and existing drugs to treat brain metastases from breast cance...
Published: 7/31/2013   |   Inventor(s):  
Keywords(s):  
Category(s): Diagnostic
Real-Time Multimodality Image Guidance System for On-the-Spot Lung Cancer Diagnosis and Treatment
Invention The invention is a minimally invasive, real-time multi-modality image guidance system for diagnosis and immediate treatment of lung cancer. Background Lung cancer is the most common cause of cancer-related death resulting in over 210,000 new lung cancers and about 160,000 deaths in the United States in 2007. The key to improving long t...
Published: 7/31/2013   |   Inventor(s):  
Keywords(s): Medical Device
Category(s): Diagnostic, Therapeutic, Imaging
Real-Time Surgical Microscope System with Diagnostic Assistance for Label-Free Identification of Tumors
Invention The invention is a portable, all fiber optical, surgical microscope integrated with a database and software to provide real-time cancer detection and diagnosis. The microscope uses high-resolution, label-free imaging to allow rapid differentiation of cancer cells from normal cells during surgery. The database and classification software p...
Published: 7/31/2013   |   Inventor(s):  
Keywords(s): Imaging
Category(s): Diagnostic, Medical Device